ID F7GUY2_MACMU Unreviewed; 921 AA.
AC F7GUY2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Oncostatin M receptor {ECO:0000313|Ensembl:ENSMMUP00000002150.3};
GN Name=OSMR {ECO:0000313|Ensembl:ENSMMUP00000002150.3,
GN ECO:0000313|VGNC:VGNC:75721};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002150.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002150.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002150.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR AlphaFoldDB; F7GUY2; -.
DR SMR; F7GUY2; -.
DR Ensembl; ENSMMUT00000002274.4; ENSMMUP00000002150.3; ENSMMUG00000001609.4.
DR VEuPathDB; HostDB:ENSMMUG00000001609; -.
DR VGNC; VGNC:75721; OSMR.
DR eggNOG; ENOG502QWRV; Eukaryota.
DR GeneTree; ENSGT00940000160851; -.
DR HOGENOM; CLU_012673_0_0_1; -.
DR TreeFam; TF338122; -.
DR Proteomes; UP000006718; Chromosome 6.
DR Bgee; ENSMMUG00000001609; Expressed in adipose tissue and 22 other cell types or tissues.
DR ExpressionAtlas; F7GUY2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..921
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023872911"
FT TRANSMEM 681..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..428
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 433..528
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 900..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 104173 MW; 62DC4B89013CEA82 CRC64;
MALFVVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSIHQSLHL QWTVHNLPYH
QELKMVFQIQ ISRIETSNVV WVGNYSTTVK WNQVLHWSWE SELPLECATH FVRIKSVIDD
ASFPEPNFWS NWSSWEEVSV QDYLGRGTLF VFPKDKLVEE GSNVTICYVS RNIQNNVSCY
LEGKQIHGEQ LDPHVTAFNL NSVPFIRNRG TNIYCEASQG NVSKGIEGIV LFVSKVLEEP
KDFSCESQDF KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ
DSQEMYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI MTWKVHSMRN
NFTYLCQIEL HGEGKMMQYD VSINVNGEYF LSELEPATEY MARVRCADAS HFWKWTEWSG
QNFTTLEAAP SEAPDVWRSV NSEPGNHTVT LFWKPLSKLH ANGKILFYNV VVENLDKPSR
SELRSIPAPA NSTKLILDRC SYQICVTANN SVGASPASII VISADPENKE VEEERIAGTE
GGFSLSWKPQ PGDVIGYVVD WCDHPQDVLQ WKNVGPNTTS TVISTDAFRP GVRYDFRIYG
LSTKRIACLL EKKTGYSQEL APSDNPHVLV DMLTSHSFTL SWKDYSTESQ PGFIQGYHVY
LKSKARQCHP RFQKAVLSAS MLIRILLPMV FCVLLIMIVC YLKSQWIKET CYPDIPDPYK
SSILSLIKFK ENPHLTIMNV SDCIPDAIEV VSKPEGTKIQ LLGTRKSLTE TELTKPNYLY
LLPTEKNHSG PGPCICFENF TYNQAASDAG SCGHVPVPPK APPSMLGLMT SPENVLKALE
KNYMNSLGEV PAGETSLNYV SQLASPMSGD KDSLPTNPVE PPHCSEYKMQ MAVPLRLALP
PPTENSSLSS ITLLDPGEHY R
//
