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Database: UniProt
Entry: F7GVT5_CALJA
LinkDB: F7GVT5_CALJA
Original site: F7GVT5_CALJA 
ID   F7GVT5_CALJA            Unreviewed;      2016 AA.
AC   F7GVT5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   18-JUL-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSCJAP00000018440};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018440, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018440, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018440}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   Ensembl; ENSCJAT00000019483; ENSCJAP00000018440; ENSCJAG00000009878.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    881    902       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    914    939       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1205   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1245   1261       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1273   1294       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1322   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1444   1470       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1529   1547       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1577       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1609       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1646   1674       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1749   1772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    943       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      953   1200       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1204   1479       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1528   1782       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2016 AA;  227008 MW;  A9BD9616C0D18C0D CRC64;
     MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYILSPFHPI
     RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGSV
     WESLDLYLSD PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT IHERRSKRRK
     RMSSGTEECG EDRLPKSDSE DGPRAVNRLS LTHGLSRTSM KPRSSRGSIF TFRRRDLGSE
     TDFADDENST AGESESHHTS LLVPWPLRRT GAQGQPSPGT AAPGHALNGK KNSTVDCNGV
     VSLLGAGDPE ATSPGSHLLR PVMLEHPLDT TTPSEEPGGP RMLTPQAPCV DGFEEPEARQ
     RALSAVSVLT SALEELEESQ RKCPPCWNRF AQRFLIWECC PLWISVKQGV KFVVTDPFAD
     LTITMCIVLN TLFMALEHYN MTSEFEDMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG
     WNIFDSIIVV LSLMELGLSR MSNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYSELRH SDSGLLPRWH MMDFFHAFLI IFRILCGEWI
     ETMWDCMEVS GQSLCLLVFL LVMVIGNLVV LNLFLALLLS SFSADNLTAP DEDRELNNLQ
     LALARIQRGL RFIKWTTWDF CCGLLRQRPQ KPAALAAPGQ LPSCIATPHS PPPPETEKAP
     PARKETRFEE GEQLGQGTPG DPETVCVPIA VAESDTDDQE EDEENSLGPE EESCKQQESQ
     PVSDGPEAPP DSRTWSQVSA TTSSEAEASA SQADWQQQRK VEPRAPGCSE TPEDSYSEGS
     TADMTNTAEL LEQIPDLGQD VKDPEDCFTE GCVRRCPCCA VDTTQAPGKV WWQLRKTCYR
     IVEHSWFETF IIFMILLSSG ALAFEDIYLE ERKTIKVLLE YADKMFTYVF VLEMLLKWVA
     YGFKKYFTNA WCWLDFLIVD VSLVSLVANT LGFAEMGPIK SLRTLRALRP LRALSRFEGM
     RVVVNALVGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCINQTEGD LPLNYTIVNN
     KSQCESLNMT GELYWTKVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRGYEEQPQW
     EYNLYMYIYF VVFIIFGSFF TLNLFIGVII DNFNQQKKKL GGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPLNKYQGF IFDVVTKQAF DVTIMFLICL NMVTMMVETD DQSPEKVNIL
     TKINLLFVAI FTGECIFKMA ALRHYYFTNS WNIFDFVVVI LSIVGTVLSD IIQKYFFSPT
     LFRVIRLARI GRILRLIRGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YSIFGMANFA
     YVKWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP NLPNSNGSRG
     DCGSPAVGIL FFTTYIIISF LIVVNMYIAI ILENFSVATE ESTEPLSEDD FDMFYETWEK
     FDPEATQFIE YSALSDFADA LSEPLRIAKP NQISLINMDL PMVSGDRIHC MDILFAFTKR
     VLGESGEMDA LKIQMEEKFM AANPSKISYE PITTTLRRKH EEVSATVIQR AFRRHLLQRS
     MKHASFLFRQ QAGSGLSEED APEREGLIAY MMNENFSRPP GLPSSSSISS TSFPPSYDSV
     TRATSDNLQV RGSDDSHSED LADFPPSLDR DRESIV
//
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