ID F7GXI8_CALJA Unreviewed; 344 AA.
AC F7GXI8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Ras association domain family member 1 {ECO:0000313|Ensembl:ENSCJAP00000009391.2};
GN Name=RASSF1 {ECO:0000313|Ensembl:ENSCJAP00000009391.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000009391.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000009391.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000009391.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7GXI8; -.
DR STRING; 9483.ENSCJAP00000009391; -.
DR Ensembl; ENSCJAT00000009926.4; ENSCJAP00000009391.2; ENSCJAG00000005126.4.
DR eggNOG; KOG4239; Eukaryota.
DR GeneTree; ENSGT00940000155664; -.
DR HOGENOM; CLU_045544_0_1_1; -.
DR InParanoid; F7GXI8; -.
DR TreeFam; TF319243; -.
DR Proteomes; UP000008225; Chromosome 15.
DR Bgee; ENSCJAG00000005126; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR CDD; cd20885; C1_RASSF1; 1.
DR CDD; cd17218; RA_RASSF1; 1.
DR CDD; cd21890; SARAH_RASSF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR033600; RASSF1_RA.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF12; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 51..105
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 198..292
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 294..341
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT REGION 179..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 39197 MW; 24202827EB7C3E14 CRC64;
MSAEPELIEL RELAPTGRAG QGRTRLERAN ALRIARGTAR NPARQLVPGR GHRFQPAGPA
THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL VCLDCCGPRD LGWEPAVERD
TNVDEPVEWE TPDLSQAEIE KKIKEYNGQI NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV
PSSKKPPSLQ DARQGPGRSA SVRRHTSFYL PKDIVKHLHV LSRTRAREVI EALLRKFLVV
DDPRKFALFE RAERHGQVYL RKLSDDEQPL RLRLLAGPSD KALSFILKEN DSGEVNWDAF
SMPELHNFLR ILQREEEAHL RQILQKYSYC RQKIQEALHA CPLG
//
