ID F7H0R1_CALJA Unreviewed; 405 AA.
AC F7H0R1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Cystathionine gamma-lyase {ECO:0000256|ARBA:ARBA00017343};
DE EC=4.4.1.1 {ECO:0000256|ARBA:ARBA00012085};
DE AltName: Full=Cysteine-protein sulfhydrase {ECO:0000256|ARBA:ARBA00031772};
DE AltName: Full=Gamma-cystathionase {ECO:0000256|ARBA:ARBA00029853};
GN Name=CTH {ECO:0000313|EMBL:JAB08470.1,
GN ECO:0000313|Ensembl:ENSCJAP00000032921.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000032921.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000032921.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB08470.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB08470.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000032921.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine
CC from L-homocysteine and L-serine: step 2/2.
CC {ECO:0000256|ARBA:ARBA00005038}.
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; GAMT01003391; JAB08470.1; -; mRNA.
DR RefSeq; XP_002751000.1; XM_002750954.4.
DR STRING; 9483.ENSCJAP00000032921; -.
DR Ensembl; ENSCJAT00000034791.5; ENSCJAP00000032921.2; ENSCJAG00000017808.5.
DR GeneID; 100401519; -.
DR KEGG; cjc:100401519; -.
DR CTD; 1491; -.
DR eggNOG; KOG0053; Eukaryota.
DR GeneTree; ENSGT00390000000312; -.
DR HOGENOM; CLU_018986_2_3_1; -.
DR OMA; YKQDGVG; -.
DR OrthoDB; 6018at2759; -.
DR TreeFam; TF300720; -.
DR UniPathway; UPA00136; UER00202.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000017808; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0004123; F:cystathionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0080146; F:L-cysteine desulfhydrase activity; IEA:UniProtKB-EC.
DR GO; GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:Ensembl.
DR GO; GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:Ensembl.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:1904831; P:positive regulation of aortic smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0019346; P:transsulfuration; IEA:Ensembl.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 2: Evidence at transcript level;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Cysteine biosynthesis {ECO:0000256|ARBA:ARBA00023192};
KW Lyase {ECO:0000313|EMBL:JAB08470.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT MOD_RES 212
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 405 AA; 44608 MW; 2A2068DEC6152C6F CRC64;
MQKKDASSHG FLPHFQHFAT QAIHVGQEPE QWTSRAVVPP ISLSTTFKQE APGQHSGFEY
SRSGNPTRNC LERAVAALDG AKYCLAFASG LAATVTITHL LKAGDHIICM DDVYGGSNRY
FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPILKMTDIE ACAHIVHKHG
DIILVVDNTF MSPYFQRPLA LGADICMCSA TKYMNGHSDV VMGLVSVNSE SLHNRLRFLQ
NSLGAVPSPI DCYLCNRGLK TLHIRMEKHF KNGMAVAQFL ESNPRVEKVI YPGLPSHPQH
ELAKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGYESLAEL PAIMTHSSVP
KKDRDVLGIS DTLIRLSVGL EDEKDLLEDL DQALKAAHPP SGSHN
//
