ID F7H173_CALJA Unreviewed; 633 AA.
AC F7H173;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=SLC6A18 {ECO:0000313|Ensembl:ENSCJAP00000020738.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000020738.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000020738.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000020738.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7H173; -.
DR STRING; 9483.ENSCJAP00000020738; -.
DR Ensembl; ENSCJAT00000021920.5; ENSCJAP00000020738.5; ENSCJAG00000036709.4.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000158906; -.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; F7H173; -.
DR OMA; VLTWVMW; -.
DR TreeFam; TF343812; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000036709; Expressed in kidney.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0140931; F:neutral L-amino acid:sodium:chloride symporter activity; IEA:Ensembl.
DR GO; GO:1990297; P:renal amino acid absorption; IEA:Ensembl.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002438; Neutral_aa_SLC6.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF109; INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR PRINTS; PR01206; ORPHTRNSPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 605..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..633
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 69786 MW; 7AAD0983DD282548 CRC64;
MAHAPEPDPA SGDLGDERPK WDNKAQYLLS CIGFAVGLGN IWRFPYLCQT YGGGAFLVPY
VIALVFEGIP LFHVELAIGQ RLRKGSIGVW TAISPYLSGL GLGCVTLSFL VSLYYNTILA
WVLWYFLNSF QHPLPWSSCP LDLNRTGFVE ECQGSSAVSY FWYRQTLNIT ADINDSGSIQ
WQLLICLAAC WAVVYMCIIR GIETTGKAIY FTASFPYLVL TIFLIRGLTL PGATKGLIYL
FTPNMQILQN PRVWLDAATQ IFFSLSLAFG GHIAFSSYNS PRNNCRKDAV AIALVNSMTS
LYASVAVFSI LGFKATNSYE HCLDRNVLIL INEFDFPEHS ISRDDYPAVL MHLTATQPRR
VAQLPLKACH LEDFLDKSAS GPGLAFIVFT EAVLHMPGAP GWAVLFFGML FTLGLSSMFG
NMEAIITPLL DKGVLPRRVP KEALTGLVCL VCFLSATCFM LQSGNYWLEI FDNFVAPLNL
LIFAFLEVVG VVYVYGMKRF CDDIAWMTGR QPGPYWRLTW RVVSPLLLLT IFVAYVTLLA
RKPLSYRAWN PQYDCGPHSS PNVSGKVSPD KTPRAGAVPL APGETLPGLG ARCLRAAVPA
SCAVGPNGRA GPAAHPVEAD VEGQERRPDT DRR
//
