GenomeNet

Database: UniProt
Entry: F7H1J0_CALJA
LinkDB: F7H1J0_CALJA
Original site: F7H1J0_CALJA 
ID   F7H1J0_CALJA            Unreviewed;       926 AA.
AC   F7H1J0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   18-JUL-2018, entry version 33.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=GBA2 {ECO:0000313|Ensembl:ENSCJAP00000018203};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018203, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018203, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018203}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Golgi apparatus membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Note=Not localized to lipid
CC       rafts. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSCJAT00000019234; ENSCJAP00000018203; ENSCJAG00000009895.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   GeneTree; ENSGT00390000010998; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:Ensembl.
DR   GO; GO:0008422; F:beta-glucosidase activity; IEA:Ensembl.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008206; P:bile acid metabolic process; IEA:Ensembl.
DR   GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   GO; GO:0016139; P:glycoside catabolic process; IEA:Ensembl.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR028944};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN      151    455       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      521    886       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   926 AA;  104667 MW;  D3451B0C19C4BACE CRC64;
     MGTQDPGNMG TGVPASEQIS CAKEDPQVYC PKETGSTKDV QVTDCKSPED NRPQKETRCC
     NPEDSGQLMA SYEGKAMGYQ VPPFGWRICL AHEFTEKRKP FQANNVSLSN MIKHIGMGLR
     YLQWWYRKTQ VEKKTPFIDM INSVPLRQIY GCPLGGIGGG TITRGWRGQF CRWQLNPGMY
     RHQTVIADQF TVCLRREGQT VYQQVLSLER PSVLRSWNWG LCGYFAFYHA LYPRAWTVYQ
     LPGQNVTLTC RQITPILPHD YQDSSLPVGV FVWDVENEGD EDLDVSIMFS MRNGLGGGDD
     APGGLWNEPF HLERDGKTVQ GLLLHHPTLP NPYTMAVAAR VTADTTVTHI TAFDPDGTGQ
     QVWQDLLQDG QLDSPAGQST PTQKGVGVAG AVCVSSKLRP RGQCRLEFSL AWDMPRIMFG
     AKGQVHYRRY TRFFGQDGDA APALSHYALC QYTEWEERIS AWQNPVLDDR LLPAWYKSAL
     FNELYFLADG GTVWLEVRED SLPQELDGNM CHLRPTLRDY GRFGYLEGQE YRMYNTYDVH
     FYASFALIML WPKLELSLQY DMALATLRED LTRRRYLMSG VMAPVKRRNV IPHDIGDPDD
     EPWLRVNAYL IHDTADWKDL NLKFVLQVYR DYYLTGDQNF LKDMWPVCLA VMESEMKFDK
     DHDGLIENGG YADQTYDGWV TTGPSAYCGG LWLAAVAVMV QMAAVCGAQD IQDKFSSILS
     RGQEAYERLL WNGRYYNYDS SSQPQSRSVM SDQCAGQWFL KACGLGEGDT EVFPTPHVVR
     ALQTIFELNV QAFAGGAMGA VNGMQPHGVP DKSSVQSDEV WVGVVYGLAA TMIQEGLTWE
     GFQTAEGCYR TVWERLGLAF QTPEAYCQQR VFRSLAYMRP LSIWAMQLAL QQQQHKKASR
     PKVKQDTGLR TGPMFGPKEA ANLSPE
//
DBGET integrated database retrieval system