ID F7H3A8_MACMU Unreviewed; 3122 AA.
AC F7H3A8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=Laminin subunit alpha 2 {ECO:0000313|Ensembl:ENSMMUP00000029154.4};
GN Name=LAMA2 {ECO:0000313|Ensembl:ENSMMUP00000029154.4,
GN ECO:0000313|VGNC:VGNC:74225};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029154.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000029154.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029154.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029154.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029154.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 9544.ENSMMUP00000029154; -.
DR PaxDb; 9544-ENSMMUP00000029154; -.
DR Ensembl; ENSMMUT00000031150.4; ENSMMUP00000029154.4; ENSMMUG00000022136.4.
DR VEuPathDB; HostDB:ENSMMUG00000022136; -.
DR VGNC; VGNC:74225; LAMA2.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000155362; -.
DR HOGENOM; CLU_000301_0_0_1; -.
DR InParanoid; F7H3A8; -.
DR OMA; SHSRINF; -.
DR TreeFam; TF335359; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000022136; Expressed in adipose tissue and 22 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 15.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR15036:SF34; LAMININ SUBUNIT ALPHA-3; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 15.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 16.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..3122
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170212"
FT DOMAIN 35..286
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 414..468
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 469..517
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 538..723
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 757..806
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 807..864
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 865..917
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 918..966
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 967..1013
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1014..1059
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1060..1105
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1106..1165
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1180..1379
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1420..1468
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1527..1573
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2145..2328
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2340..2521
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2526..2710
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2763..2934
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2939..3119
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1682..1785
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1811..1887
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1981..2008
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2034..2140
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 414..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 444..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 776..785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 835..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 889..898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 901..915
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 918..930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 920..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 939..948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 967..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 987..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1060..1072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1062..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1081..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1106..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1136..1145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1439..1448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1527..1539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1529..1546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1548..1557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2683..2710
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 3122 AA; 344160 MW; 517C82428DD5CC77 CRC64;
MPGAAGVLLL LLLSGGLRGG QAQRPQQQRR PQAHQQRGLF PAVLNLASNA LITTNATCGE
KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE
YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY
NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY
IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA
RRSLSLNIHG KYIGGGVCIN CTQNTAGINC ETCIDGFFRP KGVSPNYPRP CQPCHCNPVG
SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED
PCFGPCNCKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSDRCQSS YWTYGKIQDM
SGWYLTDLSG HIRVAPQQDD SDSPQQISIS NAEARQALPH SYYWSAPASY LGNKLPAVGG
QLTFTISYDL EEEEEDTEHV LQFMIILEGN DLRISTAQDE VYLHPSEEHV NVLLLKEESF
TIHGTHFPVS RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSVAAA
VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT
DGPYCDKCLP GFYGDPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT
GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL
CADGYFGDAV DARNCQPCRC NANGSFSEIC HSQTGQCECR ANVQGQRCDK CKPGTFGLQS
ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFSFQEGG CTACECSHLG
NNCDPKTGQC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN
CHPKFSGAKC TECSRGHWNY PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV
EGIHCDRCQP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE
ALQHTTTKGI VFQHPEIVAH MDLMREDLHW EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE
AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV
HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRRTAV TPPAHLIEKC
DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ
HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVTEGLD DYRCTACPRG
YEGQYCERCA PGYTGSPSSP GGSCQECECD PYGSLPVPCD PVTGICTCRP GATGRKCDGC
KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENMTQELK
HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE
FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA
EDELVAAEGL LKKVKKLFGE SRGKNEEMEK DLREKLADYK NKVDDAWDLL REATNKIREA
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ
TKLPPMSEEL NNKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN
ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGS LQKSFRILNE
AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRALNDTL GKLSAIPNDT AAKLQAVKDK
ARQANDTAKD VLAQIKELHQ NLDGLKKNYD KLADSVAKTN AVVKDPSKNK IIADADATVK
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP
EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP
DLTIDDSYWY RIMASRTGRN GTISVRALDG PKASIVPSTY HSTSPPGYTI LDVDANAMLF
VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT
IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL
DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE ISRTPYNILS SPDYVGVTKG
CSLENVYTVS FPKPGFVELS PVPIDVGTEI NLSFSTKNES GIILLGSGGT PAPPRRKRRQ
TGQAYYAILL NRGRLEVHLS TGARTMRKIV VRPEPNLFHD GREHSVHVER TRGIFTVQVD
ENRRYMQNLT VEQPLEVKKL FVGGAPPEFQ PSPLRNIPPF EGCVWNLVIN SVPMDFARPV
SFKNADIGRC VHQKLHEDED GAAPAETVIQ PEPVPTPAFP TPTAVLTHGP CAAESEPALL
MGSKQFGLSR NSHIAIAFDD TKVKNHLTIE LEVRTEAESG LLFYMARINH ADFATVQLRN
GLPYFSYDLG SGDTNTMIPT KINDGQWHKI KIMRSKQEGI LYVDGASNRT ISPRKADILD
VVGMLYVGGL PINYTTRRIG PVTYSIDGCI RNLHMAEAPA DLEEPTSSFH IGTCFANAQR
GTYFDGTGFA KAVGGFKVGL DLLVEFEFRT TRTTGVLLGI SSQKMDGMGI EMIDEKLMFH
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS LNPASTSADT
NDPVFVGGFP DDLKQFGLTT SIPFRGCVRS LKLTKGTGKP LEVNFAKALE LRGVQPVSCP
AN
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