ID F7H440_MACMU Unreviewed; 397 AA.
AC F7H440;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Hypoxia inducible factor 1 subunit alpha inhibitor {ECO:0000313|Ensembl:ENSMMUP00000008727.3};
GN Name=HIF1AN {ECO:0000313|Ensembl:ENSMMUP00000008727.3,
GN ECO:0000313|VGNC:VGNC:81417};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008727.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000008727.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008727.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7H440; -.
DR SMR; F7H440; -.
DR STRING; 9544.ENSMMUP00000008727; -.
DR PaxDb; 9544-ENSMMUP00000008727; -.
DR Ensembl; ENSMMUT00000009288.4; ENSMMUP00000008727.3; ENSMMUG00000006637.4.
DR VEuPathDB; HostDB:ENSMMUG00000006637; -.
DR VGNC; VGNC:81417; HIF1AN.
DR eggNOG; KOG2132; Eukaryota.
DR GeneTree; ENSGT00940000157409; -.
DR HOGENOM; CLU_016785_3_0_1; -.
DR InParanoid; F7H440; -.
DR OMA; TVSVNFW; -.
DR TreeFam; TF329609; -.
DR Proteomes; UP000006718; Chromosome 9.
DR Bgee; ENSMMUG00000006637; Expressed in hindlimb stylopod muscle and 21 other cell types or tissues.
DR ExpressionAtlas; F7H440; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0036140; F:[protein]-asparagine 3-dioxygenase activity; IBA:GO_Central.
DR GO; GO:0071532; F:ankyrin repeat binding; IBA:GO_Central.
DR GO; GO:0031406; F:carboxylic acid binding; IEA:Ensembl.
DR GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0062101; F:peptidyl-aspartic acid 3-dioxygenase activity; IEA:Ensembl.
DR GO; GO:0036139; F:peptidyl-histidine dioxygenase activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IBA:GO_Central.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
DR Gene3D; 1.10.287.1010; Clavaminate synthase-like; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR027452; FIH-1_dom_II.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR PANTHER; PTHR12461:SF93; HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..360
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
SQ SEQUENCE 397 AA; 45921 MW; 316BF5A1CFDFE630 CRC64;
MFSPTFHHPK PVCVCVCVCV CVFFFLNFFP VRNRRSFRFR RGPSLAAEMA ATAAEAVASG
SGEPREEAGA LGPAWDESQL RSYSFPTRPI PRLSQSDPRA EELIENEEPV VLTDTNLVYP
ALKWDLEYLQ ENIGNGDFSV YSASTHKFLY YDEKKMANFQ NFKPRSNREE MKFHEFVEKL
QDIQQRGGEE RLYLQQTLND TVGRKIVMDF LGFNWNWINK QQGKRGWGQL TSNLLLIGME
GNVTPAHYDE QQNFFAQIKG YKRCILFPPD QFECLYPYPV HHPCDRQSQV DFDNPDYERF
PNFQNVVGYE TVVGPGDVLY IPMYWWHHIE SLLNGGITIT VNFWYKGAPT PKRIEYPLKA
HQKVAIMRNI EKMLGEALGN PQEVGPLLNT MIKGRYN
//
