ID F7H480_MACMU Unreviewed; 971 AA.
AC F7H480;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSMMUP00000008703.4};
GN Name=RUBCN {ECO:0000313|Ensembl:ENSMMUP00000008703.4};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008703.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000008703.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008703.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7H480; -.
DR SMR; F7H480; -.
DR Ensembl; ENSMMUT00000009263.4; ENSMMUP00000008703.4; ENSMMUG00000006623.4.
DR VEuPathDB; HostDB:ENSMMUG00000006623; -.
DR GeneTree; ENSGT00940000160658; -.
DR HOGENOM; CLU_030346_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000006623; Expressed in spleen and 21 other cell types or tissues.
DR ExpressionAtlas; F7H480; baseline and differential.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd17686; RUN_RUBCN; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR048569; RUBC_PIKBD.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF21054; RUBC_PIKBD; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 48..189
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 232..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 108498 MW; CF78A251489761C3 CRC64;
MRPEGAGMEL GGGEERLAEE SRREHWQLLG HLKTTVEGLV SANSPNVWSK YGGLERLCRD
MQSILYHGLI RDQACRRQTD YWQFVKDIRW LSPHSALHVE KFICLHENGQ SSADGVSERA
VAELWLQHSL QYHCLSAQLR PLLGDRQYIR KFYTDAAFLL SDAHVTAMLQ CLEAVEQNNP
RLLAQIDASM FARKHESPLL VTKSQSLTAL PSSTYTPPTS YAQHSYFGSF SGLHQSMPNN
GSERRSTSFS LSGPPRKPQE SRGHVSPAED QTIQALPVSV SALARDSPIT PNEMSSSTLT
SPIEASWVSS QNDSPSDASE GPEYLAIGNL DPRGRTASCQ SHSSNAESSS SNLFSSSSSQ
KPDSAASSLG DQEGGEESQL SSVLRRSSFS EGQTLTVASG AKKSHIRSHS DTSIASRGAP
ESCNDKAKLR GPLPYSGQSS EVSTPSSLYM EYEGGRYLCS GEGMFRRPSE GQSLISYLSE
QDFGSCADLE KENAHFSISE SLIAAIELMK CNMMSRCLEE GEEEEDSDRE IQELKQKIRL
RRQQIRTKNL LPVYQEAEHG SFRVTSSSSQ FSSRDSAHLS DSGSADEVDE FEIQDADIRR
NTASSSRSFV SSQSFSHGFL HSTSAEAVAM GLLKQFEGMQ LPAASELEWL VPEHDAPQKL
LPIPDSLPIS PDDGQHADIY KLRIRVRGNL EWAPPRPQII FNVHPAPTRK IAVAKQNYRC
AGCGIRTEPD YIKRLRYCEY LGKYFCQCCH ENAQMVIPSR LLRKWDFSKY YVSNFSKDLL
IKIWNDPLFN VQDINSALYR KVKLLNQVRL LRVQLCHMKN MFKTCRLAKE LLDSFDTVPG
HLTEDLHLYS LNDLTATRKG ELGPRLAELT RAGAAHVERC MLCQAKGFIC EFCQNEDDII
FPFELHKCRT CEECKACYHK ACFKSGSCPR CERLQARREA LARQSLESYL SDYEEEPAEA
LALEAAVLEA T
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