ID F7H6J7_CALJA Unreviewed; 647 AA.
AC F7H6J7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DnaJ homolog subfamily C member 3 {ECO:0000256|ARBA:ARBA00039409};
GN Name=DNAJC3 {ECO:0000313|Ensembl:ENSCJAP00000006219.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000006219.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000006219.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000006219.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7H6J7; -.
DR STRING; 9483.ENSCJAP00000006219; -.
DR Ensembl; ENSCJAT00000006561.5; ENSCJAP00000006219.3; ENSCJAG00000003402.5.
DR eggNOG; KOG0624; Eukaryota.
DR GeneTree; ENSGT00940000159806; -.
DR HOGENOM; CLU_015935_0_0_1; -.
DR InParanoid; F7H6J7; -.
DR OrthoDB; 178259at2759; -.
DR TreeFam; TF105162; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000003402; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:Ensembl.
DR GO; GO:0051787; F:misfolded protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0070417; P:cellular response to cold; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1903912; P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; IEA:Ensembl.
DR GO; GO:0036494; P:positive regulation of translation initiation in response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:Ensembl.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR018704; TPR_21.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44140:SF3; DNAJ HOMOLOG SUBFAMILY C MEMBER 3; 1.
DR PANTHER; PTHR44140; LD25575P; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF09976; TPR_21; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT REPEAT 180..213
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 248..281
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 365..398
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 483..516
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 537..605
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 73..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 72550 MW; 80183F7A9F6F261F CRC64;
MDQIILLANL AQRDWPKRAV SACACGLGGR HTLPIRLPPG GRGGLEIADS SATRGRSLVS
CFHVTLSGMG RGGGLRSLSA RTTTQASPGK KRPGRRPLDG GGAPGRSVVR APPTAAFLRW
APETLRPELE PTRAGAAAAR VPARAGGPHT VPSPHSVFPF LLVLVDLQYE GAECGVNADV
EKHLELGKKL LAAGQLADAL SQFHAAVDGD PDNYIAYYRR ATVFLAMGKS KAALPDLTKV
IELKMDFTAA RLQRGHLLLK QGKLDEAEDD FKKVLKSNPS ENEEKEAQSQ LTKSDEMQRL
RSQALDAFES GDYITAIAFL DKILEVCVWD AELRELRAEC FIKEGEPRKA ISDLKAASKL
KNDNTEAFYK ISILYYQLGD HELSLSEVRE CLKLDQDHKR CFAHYKQVKK LNKLIESAEE
LIRDGRYTDA TSKYESVMKT EPSIVEYTVR SKERICHCFS KDEKPVEAIR VCSEVLQMEP
DNVNALKDRA EAYLIEEMYD EAIQDYETAQ EHNENDQQIR EGLEKAQRLL KQSQKRDYYK
ILGVKRNAKK QEIIKAYRKL ALQWHPDNFQ NEEEKKKAEK KFIDIAAAKE VLSDPEMRKK
FDDGEDPLDA ESQQGGGGNP FHRSWNSWQG FNPFSSGGPF RFKFHFN
//
