ID F7H961_MACMU Unreviewed; 2568 AA.
AC F7H961;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Stabilin 1 {ECO:0000313|Ensembl:ENSMMUP00000022843.4};
GN Name=STAB1 {ECO:0000313|Ensembl:ENSMMUP00000022843.4,
GN ECO:0000313|VGNC:VGNC:77956};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000022843.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000022843.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000022843.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR SMR; F7H961; -.
DR PaxDb; 9544-ENSMMUP00000022843; -.
DR Ensembl; ENSMMUT00000024407.4; ENSMMUP00000022843.4; ENSMMUG00000017351.4.
DR VEuPathDB; HostDB:ENSMMUG00000017351; -.
DR VGNC; VGNC:77956; STAB1.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000157928; -.
DR HOGENOM; CLU_001035_0_0_1; -.
DR TreeFam; TF331489; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000017351; Expressed in spleen and 19 other cell types or tissues.
DR ExpressionAtlas; F7H961; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.30.180.10; FAS1 domain; 7.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR24038; STABILIN; 1.
DR PANTHER; PTHR24038:SF8; STABILIN-1; 1.
DR Pfam; PF12947; EGF_3; 7.
DR Pfam; PF02469; Fasciclin; 6.
DR Pfam; PF00193; Xlink; 1.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00180; EGF_Lam; 4.
DR SMART; SM00554; FAS1; 7.
DR SMART; SM00445; LINK; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF82153; FAS1 domain; 7.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 19.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50213; FAS1; 7.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Lectin {ECO:0000256|ARBA:ARBA00022734}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..2568
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170218"
FT TRANSMEM 2474..2497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..146
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 230..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 354..492
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 504..639
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 726..766
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 816..856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 859..901
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 902..944
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1116
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1126..1251
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1328..1366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1373..1410
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1414..1452
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1453..1494
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1495..1537
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1538..1580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1580..1706
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1722..1862
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DOMAIN 1967..2005
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2012..2049
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2054..2088
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2089..2129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2130..2172
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2206..2299
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 2320..2457
FT /note="FAS1"
FT /evidence="ECO:0000259|PROSITE:PS50213"
FT DISULFID 136..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 162..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 756..765
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1356..1365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1381..1398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1400..1409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1418..1428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1995..2004
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2039..2048
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2058..2068
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2228..2297
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 2252..2273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 2568 AA; 275219 MW; 3979CACF1C4DE903 CRC64;
MAGPQGLLPL CLLAFCLAVF IRGQVLFKGC DVKTTFVTHV PCTSCAAIKK QTCPSGWLRE
LPDQITQDCR YEVQLGGSMV SMSGCRRKCR KQVVQKACCP GYWGSRCYEC PGGAETPCNG
HGTCLDGMDR NGTCVCQENF RGSACQECQD PNRFGPDCQS VCSCVHGMCN RGPRGDGSCL
CFAGYTGPHC DQELPICQEL RCPQNTQCSA EAPSCKCLPG YTQQGSECRA PNPCWPSPCS
PLALCSVSPK GQAQCHCSEN YHGDGIVCLP KDPCTDNLGG CPSNSTLCVY QKPGQAFCTC
RPGLVSINSN ASAGCFAFCS PFSCDRSATC QVTADGKTSC VCRESEVGDG RACYGHLLHE
VQKATQTGRV FLQLRVAVAM MDQGCREILT TAGPFTVLVP SISSFSSRTM NASLAQQLCR
QHIIAGQHIL EDTRTQQTRK WWTLAGQEIT VTFNQFTKYS YKYKDQPQQT FNIYKANNIA
ANGVFHVVTG LRWQPPSGTP GDPKRTIGQI LASTEAFSRF ETILENCGLP SILDGPGPFT
VFAPSNEAVD SLRDGRLIYL FTAGLSKLQE LVRYHIYNHG QLTVEKLISK GRILTMANQV
LAVNISEEGR ILLGPEGVPL QRVDVLAANG VIHMLDGILL PPTILPILPK HCSEEQHKIV
AGSCVDCQAL NTSMCPHNSV KLDIFPKECV YIHDPTGLNV LKKGCASYCN QTVTEQGCCK
GFFGPDCTQC PGGFSNPCYG KGNCSDGIQG NGACLCFPDY KGIACHICSN PNKHGDQCQE
DCGCVHGLCD NRPGSGGVCQ QGTCAPGFSG RFCNESMGDC GPTGLAQHCH LHARCVSQEG
VARCRCLDGF EGDGFSCTPS NPCSHPDRGG CSENAECVPG SLGTHHCTCH KGWSGDGRVC
VAIDECELDV RGGCHADALC SYVGPGQSRC TCKLGFAGDG YQCSPIDPCR AGNGGCHGLA
TCRAVGGGQR VCTCPPGFGG DGFSCYGDIF RELEANAHFS IFYQWFKSAG ITLPADGRVT
ALVPSEAAVR QLNPEERAFW LQPRMLPSLV RAHFLQGALF EEELARLGGQ EVATLNPTTR
WEIRNISGRV WVQNASVDVA DLLATNGVLH ILSQVLLPSR GDVPGGQGLL QQLDLVPAFS
LFRELLQRHR LVSQIEAATA YTIFVPTNRS LEAQGNSSHL DADTVRHHVV LGEALSMETL
RKGGHRNSLL GPAHWIVFYN HSGQPEVNHV PLEGPMLEAP GRSLIGLSGV LTVGSSRCLH
SHAEALREKC VNCTKKFRCT QGFQLQDTPR KSCVYRSGFS FSRGCSYTCA KKIQVPDCCP
GFFGTLCEPC PGGLGGVCSG HGQCQDRFLG SGECHCHEGF HGTACEMCEL GRYGPNCTGV
CDCAHGLCQE GLQGDGSCVC NVGWQGLRCD QKITSPQCPR KCDPNANCVQ DSAGASICAC
AAGYSGNGVF CSEVDPCAHG HGGCSPHANC TKVAPGQRTC TCQDGYMGDG ELCQEINSCL
IHHGGCHIHA ECIPTGPQQV SCSCREGYRG DGIRTCELLD PCSKNNGGCS PYATCKSTGD
GQRTCTCDTA NTVGDGLTCR ARVGLELLRD KHASFFSLRL LEYKELKGDG PFTIFVPHAD
LMSNLSQDEL ARIRAHRQLV FRYHVVGCRR LRSEDLLEQG YATALSGHPL RFSEREGSIY
LNDFARVVSS DHEAVNGILH FIDRVLLPPD ALHWEPDDEP IPRRNVTAAA QGFGYKIFSG
LLKVASLLPL LREASHRPFT MLWPTDAAFR ALPPDRQAWL YHEDHRDKLA AILRGHMIRN
VEALASDLPN LGPLRTMHGT PISFACSRTR PGELMVGEDD ARIVQRHLPF EGGLAYGIDQ
LLEPPGLGAR CDHFETRPLR LNTCSICGLE PPCPEGSQEQ GSPEACWRLY PKFWTSPPLR
SLGLHSVWVQ HSLWARPQGL GRGCHRNCVT TTWKPSCCPG HYGSECQACP GGPSSPCSDR
GMCMDGMSGS GQCLCRSGFA GTACELCAPG AFGPHCQACR CTVHGRCDEG LGGSGSCFCD
EGWTGSHCEV QLELQPVCTP PCAPKAVCRA GNSCECSLGY EGDGRVCTVA DLCQDGHGGC
SEHANCSQVG TAVTCTCLPD YEGDGWSCRA RNPCTDGHRG GCSEHADCLS TGLNTRRCEC
HAGYVGDGLQ CLEELEPPVD RCLGRPPPCH SDAVCTDLHF QEKRAGVFHL QATSGPYGLN
FSEAEAACKA QGAVLASFPQ LSAAQQLGFH LCLMGWLANG SAAHPVVFPV ADCGNGRVGI
VSLGARKNLS ERWDAYCFRV QDVACRCRDG FVGDGISTCN GKLLDVLAAT ANFSTFYGML
LGYANATQRG LDFLDFLDDE LTYKTLFVPV NEGFVDNMTL SGPDLELHAS NATLLSANAS
QGKLLPAHSG LSLIISDAGP DNSSWAPVAP GTVVVSHVIV WDIVAFNGII HALASPLLAP
PQPQAVLAPK APPVAAGVGA VLAAGALLGL VAGALYLRAQ GKPTGFGFSA FQAEEDAADD
FSPWQEGTNP TLVSVPNPVF GSDTFCEPFH DSLLEEDFPD TQRILTVK
//
