ID F7H9B7_CALJA Unreviewed; 801 AA.
AC F7H9B7; U3EIN0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Transferrin receptor 2 {ECO:0000313|Ensembl:ENSCJAP00000027986.4};
DE SubName: Full=Transferrin receptor protein 2 isoform 1 {ECO:0000313|EMBL:JAB50753.1};
GN Name=TFR2 {ECO:0000313|EMBL:JAB50753.1,
GN ECO:0000313|Ensembl:ENSCJAP00000027986.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000027986.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000027986.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB50753.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB50753.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000027986.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; GAMP01002002; JAB50753.1; -; mRNA.
DR RefSeq; XP_002744042.1; XM_002743996.3.
DR RefSeq; XP_017821845.1; XM_017966356.1.
DR STRING; 9483.ENSCJAP00000027986; -.
DR MEROPS; M28.973; -.
DR Ensembl; ENSCJAT00000029573.5; ENSCJAP00000027986.4; ENSCJAG00000015136.5.
DR GeneID; 100395993; -.
DR KEGG; cjc:100395993; -.
DR CTD; 7036; -.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_5_0_1; -.
DR OMA; QVVFNNH; -.
DR OrthoDB; 2428249at2759; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000015136; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
DR GO; GO:0004998; F:transferrin receptor activity; IEA:Ensembl.
DR GO; GO:0071281; P:cellular response to iron ion; IEA:Ensembl.
DR GO; GO:0140298; P:endocytic iron import into cell; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; IEA:Ensembl.
DR GO; GO:1903319; P:positive regulation of protein maturation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; IEA:Ensembl.
DR GO; GO:0033572; P:transferrin transport; IEA:Ensembl.
DR CDD; cd09848; M28_TfR; 1.
DR CDD; cd02128; PA_TfR; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR InterPro; IPR037324; TfR1/2_PA.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR PANTHER; PTHR10404:SF33; TRANSFERRIN RECEPTOR PROTEIN 2; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:JAB50753.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..305
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 412..611
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 801 AA; 88800 MW; FE8EA3CA46FACCE1 CRC64;
MERLWGLLQR AQQLSPRSSQ TVYQRVEGPR KGCLEEEEED REEGAETLAH FCPMELKGPE
SLGSRPGQPN LIPWAAAGRR AAPYLVLMAL LIFTGAFLLG YVTFRGSCQT CGDSVLVVSE
DVNYETGLDS HGGTLYWNDL QAMFLRFLGE GRLEDTIRQT SLRERVAGSA GMAALTQDIR
VAFSRQKLDH VWTDTHYVGL QFPDPAHPNT LHWVDEAGKV AEQLPLEDPE VYCPYSAIGN
VTGDLVYAHY GRPEDLQELR ARGVDPAGSL LLVRVGVISF AQKVTNAQDF GARGVLIYPE
PADFSQDPHK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS
ADIASRLLRK LKGPVAPQEW QGHLLGSPYH LGPGPGMRLE VNNHRTSTPI NNIFGCIEGR
SEPDHYVVIG AQRDAWGPGA AKSAVGTAIL LELVRTFASM VNNGFRPRRS LLFISWDGSD
FGSVGSTEWL EGYLSVLHLK AVVYVSLDNA VLGDDKFYAK TSPLLTSLIE SVLKQVDSPN
HSGQTLYEQV VFTNPIWDAE VIRPLPMDSS AYSFTAFAGV PAVEFSFMEE DQAYPFLHTK
EDTYEKLHKV LRGRLPAVAQ AVAQLAGQLL IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF
SGELKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLTRMYNVRI MRVEFYFLSQ
YVSPADSPFR HIFLGRGDHT LGALLDHLRL LRSNSSRTPG ATSSAGFQES RFRRQLALLT
WTLQGAANAL SGDVWNIDNN F
//
