GenomeNet

Database: UniProt
Entry: F7HB93_MACMU
LinkDB: F7HB93_MACMU
Original site: F7HB93_MACMU 
ID   F7HB93_MACMU            Unreviewed;      4819 AA.
AC   F7HB93;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSMMUP00000003881};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSMMUP00000003881};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003881, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000003881, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003881,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000003881}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003881};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; JSUE03021655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03021661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9544.ENSMMUP00000003881; -.
DR   Ensembl; ENSMMUT00000004113; ENSMMUP00000003881; ENSMMUG00000002897.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155288; -.
DR   InParanoid; F7HB93; -.
DR   Proteomes; UP000006718; Chromosome 19.
DR   Bgee; ENSMMUG00000002897; Expressed in 9 organ(s), highest expression level in cerebellum.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4342   4362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4430   4453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4619   4641       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4700   4723       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1176   1390       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1689   1739       {ECO:0000256|SAM:Coils}.
FT   COILED     2732   2752       {ECO:0000256|SAM:Coils}.
FT   COILED     3479   3499       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4819 AA;  540890 MW;  273EAC96FDE64209 CRC64;
     MADAEGEDDV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
     LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSRMYLSCL
     TTSRSMTDKL AFDVGLQEDA IGEACWWTTH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
     RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL ALTEDQGLVV
     VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
     PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF
     SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE
     GMLSLVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS
     TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
     VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG RAEGTTQYSK
     WYFEVMVDEV TPFLTAQATH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WTGHVARPVT SPGQHLLAPE DVVSCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV
     SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG
     PSRCLSHTDF VPCPVDTVQV LPPGQHGETH SLLKIQKISW AWWWVPVISA TQEAEMETLW
     GDPSSIPHAL NLTLRMSVFI YLSLPASLSL HFSVCLPTPC LLWPSSQGQR WHLGSEPFGR
     PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDGFLPV CSLGPGQVGH
     LNLGQDVSSL RFFAICGLQE GFEPFAINMQ RPVTTWFSKG LPQFEPVPLE HPHYEVARVD
     GTVDTPPCLR LTHRTWGSQN SLVEMLFLRL SLPVQFHQHF RCTAGATPLA PPGLQPPAED
     EARAAEPDPD YENLRRSAGG WGEAENGKEG TAKEGAPGGT PQAGGEAQPA RAENEKDATT
     EKNKKRGFLF KAKKVAMMTQ PPATPTLPRL PHDVVPADNR DDPEIILNTT TYYYSVRVFA
     GQEPSCVWVG WVTPDYHQHD MSFDLSKVRV VTVTMGDEQG NIHSSLKCSN CYMVWGGDFV
     SPGQQGRISH TDLVIGCLVD LATGLMTFTA NGKESNTFFQ VEPNTKLFPA VFVLPTHQNV
     IQFELGKQKN IMPLSAAMFQ SERKNPAPQC PPRLEMQMLM PVSWSRMPNH FLQVETRRAG
     ERLGWAVQCR EPLTMMALHI PEENRCMDIL ELSERLDLQR FHSHTLRLYR AVCALGNNRV
     AHALCSHVDQ AQLLHALEDA HLPGPLRAGY YDLLISIHLE SACRSRRSML SEYIVPLTPE
     TRAITLFPPG RSTENGHPRH GLPGVGVSTS LRPPHHFSAP CFVAALPAAG AAEAPARLSP
     AIPLEALRDK ALRMLGEAVR DGGQHARDPV GGSVEFQFVP VLKLVSTLLV MGIFGDEDVK
     QILKMIEPEV FTEEEEEEEE EEEEEEDEEE KEEDEEETAQ EKEDEEKEEE EAAGGEKEEG
     LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQA NQRSRYGLLM
     KAFSMTAAET ARRTREFRSP PQEQINMLLQ FKDGTDEEDC PLPEEIRQDL LDFHQDLLAH
     CGIQLDGEEE ELEEETTLGS RLMSLLEKVR LVKKEEEKPE EERPAEESKP RSLQELVSHM
     VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISPSSVED TMSLLECLGQ
     IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGESK
     EIRFPKMVTS CCRFLCYFCR ISRQNQRSMF DHLSYLLENS GIGLGMQGST PLDVAAASVI
     DNNELALALQ EQDLEKVVSY LAGCGLQSCP MLVAKGYPDI GWNPCGGERY LDFLRFAVFV
     NGESVEENAN VVVRLLIRKP ECFGPALRGE GGSGLLAAIE EAIRISEDPA RDGPGIRRDR
     RREHFGEEPP EENRVHLGHA IMSFYAALID LLGRCAPEMH LIQACKGEAL RIRAILRSLV
     PLEDLVGIIS LPLQMPTLGK DGALVQPKMS ASFVPDHKAS MVLFLDRVYG IENQDFLLHV
     LDVGFLPDMR AAASLDTATF STTEMALALN RYLCLAVLPL ITKCAPLFAG TEHRAIMVDS
     MLHTVYRLSR GRSLTKAQRD VIEDCLMALC RYIRPSMLQH LLRRLVFDVP ILNEFAKMPL
     KLLTNHYERC WKYYCLPTGW ANFGVTSEEE LHLTRKLFWG IFDSLAHKKY DPELYRMAMP
     CLCAIAGALP PDYVDASYSS KAEKKATVDA EGNFDPRPVE TLNVIIPEKL DSFINKFAEY
     THEKWAFDKI QSNWSYGENI DEELKTHPML RPYKTFSEKD KEIYRWPIKE SLKAMIAWEW
     TIEKARDGEE EKTEKKKTRK ISQSAQTYDP REGYNPQPPD LSAVTLSREL QAMAEQLAEN
     YHNTWGRKKK QELEAKGGGT HPLLVPYDTL TAKEKARDRE KAQELLKFLQ MNGYAVTRGL
     KDMELDSSSI EKRFAFGFLQ QLLRWMDISQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI
     LLPLINQYFT NHCLYFLSTP AKVLGSGGHA SNKEKEMITS LFCKLAALVR HRVSLFELVF
     PCCPSRTVMK SGPEIVKAGL RSFFESASED IEKMVENLRL GKVSQARTQV KGVGQNLTYT
     TVALLPVLTT LFQHIAQHQF GDDVILDDVQ VSCYRTLCSI YSLGTTKNIY VEKLRPALGE
     CLARLAAAMP VAFLEPQLNE YNACSVYTTK SPRERAILGL PNSVEEMCPD IPVLERLMAD
     IGGLAESGAR YTEMPHVIEI ALPMLCSYLP RWWERGPEAP PPALPAGAPP PCTAVTSDHL
     NSLLGNILRI IVNNLGIDEA SWMKRLAVFA QPIVSRARPE LLQSHFIPTI GRLRKRAGKV
     VSEEEQLRLE AKAEAQEGEL LVRDEFSVLC RDLYALYPLL IRYVDNNRAQ WLTEPNPSAE
     ELFRMVGEIF IYWSKSHNFK REEQNFVVQN EINNMSFLTA DNKSKMAKVG SGGSDQERTK
     KKRRGDRYSV QTSLIVATLK KMLPIGLNMC APTDQDLITL AKTRYALKDT DEEVREFLNN
     NLHLQGKVEG SPSLRWQMAL YWGVPGREED ADDPEKIVRR VQEVSAVLYH LDQTEHPYKS
     KKAVWHKLLS KQRRRAVVAC FRMTPLYNLP THRACNMFLE SYKAAWILTE DHSFEDRMID
     DLSKAGEQEE EEEEVEEKKP DPLHQLVLHF SRTALTEKSK LDEDYLYMAY ADIMAKSCHL
     EEGGENGEGE EEVEVSFEEK EMEKQRLLYQ QARLHTRGAA EMVLQMISAC KGETGAMVSS
     TLKLGISILN GGNAEVQQKM LDYLKDKKEV GFFQSIQALM QTCSVLDLNA FERQNKAEGL
     GMVNEDGTVI NRQNGEKVMA DDEFTQDLFR FLQLLCEGHN NDFQNYLRTQ TGNTTTINII
     ICTVDYLLRL QESISDFYWY YSGKDVIEEQ GKRNFSKAMS VAKQVFNSLT EYIQGPCTGN
     QQSLAHSRLW DAVVGFLHVF AHMMMKLAQD SSQIELLKEL LDLQKDMVVM LLSLLEGNVV
     NGTIARQMVD MLVESSSNVE MILKFFDMFL KLKDIVGSEA FQDYVTDPRG LISKKDFQKA
     MDSQKQFSGP EIQFLLSCSE ADENEMINCE EFANRFQEPA RDIGFNVAVL LTNLSEHVPH
     DPRLHNFLEL AESILEYFRP YLGRIEIMGA SRRIERIYFE ISETNRAQWE MPQVKESKRQ
     FIFDVVNEGG EAEKMELFVS FCEDTIFEMQ IAAQISEPEG EPETDEDEGA AEGRWAEGAR
     RAEARRATRG LAAPWPACAA HYRRPAGARA AACGASRPRW PATARARGGA LRGGRAGALA
     CLWGSLFAAA AVEAQKKVTV TELLAGMPDP TSDEVHGSSR AGPGGEADGE LPRGGGDAAE
     GAGDEEEAVD EAGPGGADGA VAVTDGGPFR PEGAGGLGDM GDTTPAEPPT PEGSPILKRK
     LGVDGVEEEL PPEPEPEPEL EPEKADAENG EKEEVPEPPP EPPKKQAPPS PPPKKEEAGG
     EFWGELEVQR VKFLNYLSRN FYTLRFLALF LAFAINFILL FYKVSDSPPG EDDMEGSAAG
     DVSGAGSGGG SGWGLGAGEE AEGDEDENMV YYFLEESTGY MEPALRCLSL LHTLVAFLCI
     IGYNCLKVPL VIFKREKELA RKLEFDGLYI TEQPEDDDVK GQWDRLVLNT PSFPSNYWDK
     FVKRKVLDKH GDIYGRERIA ELLGMDLATL EITAHNERKP DPPPGLLTWL MSIDVKYQIW
     KFGVIFTDNS FLYLGWYMVM SLLGHYNNFF FAAHLLDIAM GVKTLRTILS SVTHNGKQLV
     MTVGLLAVVV YLYTVVAFNF FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG
     DEIEDPAGDE YELYRVVFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC
     FICGIGSDYF DTTPHGFETH TLEEHNLANY MFFLMYLINK DETEHTGQES YVWKMYQERC
     WDFFPAGDCF RKQYEDQLS
//
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