ID F7HDT5_CALJA Unreviewed; 311 AA.
AC F7HDT5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=TIMELESS-interacting protein {ECO:0000256|ARBA:ARBA00018750, ECO:0000256|RuleBase:RU366049};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000024329.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000024329.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000024329.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in the control of DNA replication and
CC the maintenance of replication fork stability.
CC {ECO:0000256|RuleBase:RU366049}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU366049}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000256|ARBA:ARBA00006075,
CC ECO:0000256|RuleBase:RU366049}.
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DR AlphaFoldDB; F7HDT5; -.
DR STRING; 9483.ENSCJAP00000024329; -.
DR Ensembl; ENSCJAT00000025730.5; ENSCJAP00000024329.5; ENSCJAG00000013242.5.
DR eggNOG; KOG3004; Eukaryota.
DR GeneTree; ENSGT00390000005764; -.
DR HOGENOM; CLU_074595_0_0_1; -.
DR InParanoid; F7HDT5; -.
DR TreeFam; TF313290; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000013242; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0031297; P:replication fork processing; IEA:UniProtKB-UniRule.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; TIMELESS INTERACTING-RELATED; 1.
DR PANTHER; PTHR13220:SF11; TIMELESS-INTERACTING PROTEIN; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU366049};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU366049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366049};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 102..182
FT /note="Chromosome segregation in meiosis protein 3"
FT /evidence="ECO:0000259|Pfam:PF07962"
FT REGION 55..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 35588 MW; EA4B2DDF47D06917 CRC64;
MPREFPSLAR SALSLLARVR VWRLCSTCGE SSLAEEEMLE PENGMIDVPD YEHVEDEIFP
PFPPPPSPER QDGERAEPDE EAGSGAPVPV PPKRTVKRNI PKLDAQRLIS ERGLPALRHV
FDKAKFKGKG HEAEDLKTLI RHMEHWAHRL FPKLQFEDFV DRVEYLGSKK EVQTCLKRIR
LDLPILHEDF VNNNGEVMEN NEHDVTASEL DPFLTNSSES EMFASQSSKS LTEEQQQRIE
RNKQLALERR QAKLLSNSQS LGNDMLMNAP RAQTVEELNT DEDQKEESNG LKEDILDNSL
RALEEFSRLL L
//
