ID F7HG05_MACMU Unreviewed; 1892 AA.
AC F7HG05;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Afadin, adherens junction formation factor {ECO:0000313|Ensembl:ENSMMUP00000027697.4};
GN Name=AFDN {ECO:0000313|Ensembl:ENSMMUP00000027697.4,
GN ECO:0000313|VGNC:VGNC:69818};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000027697.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000027697.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000027697.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F7HG05; -.
DR STRING; 9544.ENSMMUP00000027697; -.
DR Ensembl; ENSMMUT00000029596.4; ENSMMUP00000027697.4; ENSMMUG00000021044.4.
DR VEuPathDB; HostDB:ENSMMUG00000021044; -.
DR VGNC; VGNC:69818; AFDN.
DR GeneTree; ENSGT00940000155237; -.
DR InParanoid; F7HG05; -.
DR OMA; YRCAQDE; -.
DR TreeFam; TF350731; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000021044; Expressed in lung and 22 other cell types or tissues.
DR ExpressionAtlas; F7HG05; baseline.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22711; FHA_AFDN; 1.
DR CDD; cd15471; Myo5p-like_CBD_afadin; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR CDD; cd01781; RA2_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR037977; CBD_Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 39..134
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 247..349
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 654..901
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 1000..1086
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 129..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1163..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1368
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1399..1435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1704
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1772..1790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1861..1876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1877..1892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1892 AA; 213736 MW; 8A066D99780BC84B CRC64;
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI
RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG EERRLDIDEK PLVVQLNWNK
DDREGRFVLK NENDAIPPKK AQSNGPEKQE KEGVIQNFKR TLSKKEKKEK KKREKEALRQ
ASDKDDRPFQ GEDVENSRLA AEVYKDMPET SFTRTISNPE VVMKRRRQQK LEKRMQEFRS
SDGRPDSGGT LRIYADSLKP NIPYKTILLS TTDPADFAVA EALEKYGLEK ENPKDYCIAR
VMLPPGAQHS DEKGAKEIIL DDDECPLQIF REWPSDKGIL VFQLKRRPPD HIPKKTKKHL
EGKTPKGKER ADGSGYGSAL PPEKLPYLVE LSPDGSDSRD KPKLYRLQLS VTEVGTEKLD
DSSIQLFGPG IQPHHCDLTN MDGVVTVTPR SMDAETYVEG QRISETTMLQ SGMKVQFGAS
HVFKFVDPTQ DHALAKRSVD GGLMVKGPRH KPGIVQETTF DLGGDIHSGT ALPTSKSTTR
LDSDRVSSAS STAERGMVKP MIRVEQQPDY RRQESRTQDA SGPELILPAS IEFRESSEDS
FLSAIINYTN SSTVHFKLSP TYVLYMACRY VLSNQYRPDI SPTERTHKVI AVVNKMVSMM
EGVIQEVDQV DQKQKNIAGA LAFWMANASE LLNFIKQDRD LSRITLDAQD VLAHLVQMAF
KYLVHCLQSE LNNYMPAFLD DPEENSLQRP KIDDVLHTLT GAMSLLRRCR VNAALTIQLF
SQLFHFINMW LFNRLVTDPD SGLCSHYWGA IIRQQLGHIE AWAEKQGLEL AADCHLSRIV
QATTLLTMDK YAPDDIPNIN STCFKLNSLQ LQALLQNYHC APDEPFIPTD LIENVVAVAE
NTADELARSD GREVQLEEDP DLQLPFLLPE DGYSCDVVRN IPNGLQEFLD PLCQRGFCRL
IPHTRSPGTW TIYFEGADYE SHLLRENTEL AQPLRKEPEI ITVTLKKQNG MGLSIVAAKG
AGQDKLGIYV KSVVKGGAAD VDGRLAAGDQ LLSVDGRSLV GLSQERAAEL MTRTSSVVTL
EVAKQGAIYH GLATLLNQPS PMMQRISDRR GSGKPRPKSE GFELYNNSAQ NGSPESPQLP
WAEYSEPKKL PGDDRLTKNR ADHRSSPNVA NQPPSPGGKS AYASGTAAKI TSVSTGNLCT
EEQTPPPRPE AYPIPTQTYT REYFTFPASK SQDRMAPPQN QWPNYEEKPH MHTDSNHSSI
AIQRVTRSQE ELREDKAYQL ERHRIEAAMD RKSDSDMWIN QSSSLDSSTS SQEHLNHSSK
SVTPASTLTK SGPGRWKTPA AIPATPVAVS QPIRTDLPPP PPPPPVHYAG DFDGMSMDLP
LPPPPSTNQI GLPSAQVAAA ERKKREEHQR WYEKEKARLE EERERKRREQ ERKLGQMRTQ
SLNPAPFSPL TTQQMKPEKP STLQRPQETV IRELQPQQQP RTIERRDLQY ITVSKEELSS
GDSLSPDPWK RDAKEKLEKQ QQMHIVDMLS KEIQELQSKP DRSAEESDRL RKLMLEWQFQ
KRLQESKQKD EDDEEEEDDD VDTMLIMQRL EAERRARLQD EERRRQQQLE EMRKREAEDR
ARQEEERRRQ EEERTKRDAE EKRRQEEGYY SRLEAERRRQ HDEAARRLLE PEAPGLCRPP
LPRDYEPPSP SPAPGAPPPP PQRNASYLKT QVLSPDSLFT AKFVAYNEEE EEEDCSLAGQ
DKYSSTRMSH GDLLPAPLKP RPPPCQPRPA SDGIFLSNSF QPSPAKANST AHKKGQPPPP
PKKSSSYHPS HCKGPNSYPG SAGAAVGAHD AYRDAKEKRS KSQDADLPGS SGAPENLTFK
ERQRLFSQGQ DVSNKVKASR KLTELENELN TK
//
