ID F7HG08_MACMU Unreviewed; 1785 AA.
AC F7HG08;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Afadin, adherens junction formation factor {ECO:0000313|Ensembl:ENSMMUP00000027695.4};
GN Name=AFDN {ECO:0000313|Ensembl:ENSMMUP00000027695.4,
GN ECO:0000313|VGNC:VGNC:69818};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000027695.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000027695.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000027695.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F7HG08; -.
DR Ensembl; ENSMMUT00000029594.4; ENSMMUP00000027695.4; ENSMMUG00000021044.4.
DR VEuPathDB; HostDB:ENSMMUG00000021044; -.
DR VGNC; VGNC:69818; AFDN.
DR eggNOG; KOG1892; Eukaryota.
DR GeneTree; ENSGT00940000155237; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000021044; Expressed in lung and 22 other cell types or tissues.
DR ExpressionAtlas; F7HG08; baseline.
DR GO; GO:0005911; C:cell-cell junction; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22711; FHA_AFDN; 1.
DR CDD; cd15471; Myo5p-like_CBD_afadin; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR CDD; cd01781; RA2_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR037977; CBD_Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 14..109
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 222..324
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 629..869
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 968..1054
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 104..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1336
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1643..1672
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1754..1769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 201935 MW; F3C870C088078F32 CRC64;
MEPGRRAVLQ DLEFHGVMRF YFQDKAAGNF ATKCIRVSST ATTQDVIETL AEKFRPDMRM
LSSPKYSLYE VHVSGEERRL DIDEKPLVVQ LNWNKDDREG RFVLKNENDA IPPKKAQSNG
PEKQEKEGVI QNFKRTLSKK EKKEKKKREK EALRQASDKD DRPFQGEDVE NSRLAAEVYK
DMPETSFTRT ISNPEVVMKR RRQQKLEKRM QEFRSSDGRP DSGGTLRIYA DSLKPNIPYK
TILLSTTDPA DFAVAEALEK YGLEKENPKD YCIARVMLPP GAQHSDEKGA KEIILDDDEC
PLQIFREWPS DKGILVFQLK RRPPDHIPKK TKKHLEGKTP KGKERADGSG YGSALPPEKL
PYLVELSPDG SDSRDKPKLY RLQLSVTEVG TEKLDDSSIQ LFGPGIQPHH CDLTNMDGVV
TVTPRSMDAE TYVEGQRISE TTMLQSGMKV QFGASHVFKF VDPTQDHALA KRSVDGGLMV
KGPRHKPGIV QETTFDLGGD IHSGTALPTS KSTTRLDSDR VSSASSTAER GMVKPMIRVE
QQPDYRRQES RTQDASGPEL ILPASIEFRE SSEDSFLSAI INYTNSSTVH FKLSPTYVLY
MACRYVLSNQ YRPDISPTER THKVIAVVNK MVSMMEGVIQ KQKNIAGALA FWMANASELL
NFIKQDRDLS RITLDAQDVL AHLVQMAFKY LVHCLQSELN NYMPAFLDDP EENSLQRPKI
DDVLHTLTGA MSLLRRCRVN AALTIQLFSQ LFHFINMWLF NRLVTDPDSG LCSHYWGAII
RQQLGHIEAW AEKQGLELAA DCHLSRIVQA TTLLTMDKYA PDDIPNINST CFKLNSLQLQ
ALLQNYHCAP DEPFIPTDLI ENVVAVAENT ADELARSDGR EVQLEEDPDL QLPFLLPEDG
YSCDVVRNIP NGLQEFLDPL CQRGFCRLIP HTRSPGTWTI YFEGADYESH LLRENTELAQ
PLRKEPEIIT VTLKKQNGMG LSIVAAKGAG QDKLGIYVKS VVKGGAADVD GRLAAGDQLL
SVDGRSLVGL SQERAAELMT RTSSVVTLEV AKQGAIYHGL ATLLNQPSPM MQRISDRRGS
GKPRPKSEGF ELYNNSAQNG SPESPQLPWA EYSEPKKLPG DDRLTKNRAD HRSSPNVANQ
PPSPGGKSAY ASGTAAKITS VSTGNLCTEE QTPPPRPEAY PIPTQTYTRE YFTFPASKSQ
DRMAPPQNQW PNYEEKPHMH TDSNHSSIAI QRVTRSQEEL REDKAYQLER HRIEAAMDRK
SDSDMWINQS SSLDSSTSSQ EHLNHSSKSV TPASTLTKSG PGRWKTPAAI PATPVAVSQP
IRTDLPPPPP PPPVHYAGDF DGMSMDLPLP PPPSTNQIGL PSAQVAAAER KKREEHQRWY
EKEKARLEEE RERKRREQER KLGQMRTQSL NPAPFSPLTT QQMKPEKPST LQRPQETVIR
ELQPQQQPRT IERRDLQYIT VSKEELSSGD SLSPDPWKRD AKEKLEKQQQ MHIVDMLSKE
IQELQSKPDR SAEESDRLRK LMLEWQFQKR LQESKQKDED DEEEEDDDVD TMLIMQRLEA
ERRARLQDEE RRRQQQLEEM RKREAEDRAR QEEERRRQEE ERTKRDAEEK RRQEEGYYSR
LEAERRRQHD EAARRLLEPE APGLCRPPLP RDYEPPSPSP APGAPPPPPQ RNASYLKTQV
LSPDSLFTAK FVAYNEEEEE EDCSLAGPNS YPGSAGAAVG AHDAYRDAKE KRSKSQDADL
PGSSGAPENL TFKERQRLFS QGQDVSNKVK ASRKLTELEN ELNTK
//
