ID   F7HI83_CALJA            Unreviewed;      1121 AA.
AC   F7HI83;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
GN   Name=SMG7 {ECO:0000313|Ensembl:ENSCJAP00000009539.4};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000009539.4, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000009539.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000009539.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC       {ECO:0000256|RuleBase:RU369098}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F7HI83; -.
DR   Ensembl; ENSCJAT00000010081.4; ENSCJAP00000009539.4; ENSCJAG00000005135.5.
DR   GeneTree; ENSGT00940000158333; -.
DR   OrthoDB; 1356823at2759; -.
DR   Proteomes; UP000008225; Chromosome 18.
DR   Bgee; ENSCJAG00000005135; Expressed in cerebellum and 6 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF5; NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW   ECO:0000256|RuleBase:RU369098}; Nucleus {ECO:0000256|RuleBase:RU369098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          40..153
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          156..415
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   REGION          605..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          681..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          972..1039
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1054..1073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1089..1121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..631
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..760
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        972..1014
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1054..1069
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  125652 MW;  5F9676CD275D5719 CRC64;
     MSLRSNSKLG PAEVWTSRQA LQDLYQKMLV TDLEYALDKK VEQDLWNHAF KNQITTLQGQ
     AKNRANPNRS EVQANLSLFL EAASGFYTQL LQELCTVFNV DLPCRVKSSQ LGIISNKQTH
     TSAIVKPQSS SCSYICQHCL VHLGDIARYR NQTSQAESYY RHAAQLVPSN GQPYNQLAIL
     ASSKGDHLTT IFYYCRSIAV KFPFPAASTN LQKALSKALE SRDEVKTKWG VSDFIKAFIK
     FHGHVYLSKS LEKLSPLREK LEEQFKRLLF QKAFNSQQLV HVTVINLFQL HHLRDFSNET
     EQHSYSQDEQ LCWTQLLALF MSFLGILCKC PLQNESPEES YNAYPLPAVK VSMDWLRLRP
     RVFQEAVVDE RQYIWPWLIS LLNSFHPHEE DLSSTNATPL PEEFELQGFL ALRPSFRNLD
     FSKGHQGITG DKEGQQRRIR QQRLISIGKW IADNQPRLMQ CENEVGKLLF ITEIPELILE
     DPSEAKENLI LQETSVIESL AADGSPGLKS VLSTSRNLSN NCDTGEKPMV TFKENIKPRE
     VNRDQGRSFP PKEVRRDYSK GITVTKNDGK KDNNKRKTET KKCTLEKLQE TGKQNVAVQV
     KSQTELRKTP VSEARKTPVT QTPTQASNSQ FIPIHHPGAF PPLPSRPGFP PPTYVIPPPV
     AFSMGSGYTF PAGVSVPGTF LQPTAHSPAG NQVQAGKQSH IPYSQQRPSG PGPMNQGPQQ
     SQPPSQQPLT SLPAQPTAQP TSQLQVQALT QQQQSPTKAV PALGKSPPHH SGFQQYQQAD
     ASKQLWNPPQ VQGPLGKIMP VKQPYYLQTQ DPIKLFEPSL QPPVMQQQPL EKKMKPFPME
     PYNHNPSEVK VPEFYWDSSY SMADNRPVMA QQANMDRRGK RQTVFRPEQD PVPRMPFEKS
     LLEKPSELMS HSSSFLSLTG FSLNQERYPN NSMFNEVYGK NLAPSSKAEL NPSMAPQETS
     LYSLFEGTPW SPSLPASSDH STPASQSPHS SNPSSLPSSP PTHNHNSVPF SNFGPIGTPD
     NRDRRTADRW KTDKPAMGGF GIDYLSATSS SESNWHQAST SSGPWTGHGP SMEDSSAVLM
     ESLKSIWSSS MMHPGPSALE QLLMQQKQKQ QRGQGTMNPP H
//