ID F7HLC4_MACMU Unreviewed; 1104 AA.
AC F7HLC4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Calsyntenin 1 {ECO:0000313|Ensembl:ENSMMUP00000008183.3};
GN Name=CLSTN1 {ECO:0000313|Ensembl:ENSMMUP00000008183.3,
GN ECO:0000313|VGNC:VGNC:82127};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000008183.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000008183.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000008183.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035006}.
CC -!- SIMILARITY: Belongs to the CTNNBIP1 family.
CC {ECO:0000256|ARBA:ARBA00006505}.
CC -!- SIMILARITY: Belongs to the calsyntenin family.
CC {ECO:0000256|ARBA:ARBA00035015}.
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DR AlphaFoldDB; F7HLC4; -.
DR Ensembl; ENSMMUT00000008708.4; ENSMMUP00000008183.3; ENSMMUG00000006225.4.
DR VEuPathDB; HostDB:ENSMMUG00000006225; -.
DR VGNC; VGNC:82127; CLSTN1.
DR GeneTree; ENSGT00950000183086; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000006225; Expressed in dorsolateral prefrontal cortex and 21 other cell types or tissues.
DR ExpressionAtlas; F7HLC4; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0042988; F:X11-like protein binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.10.490; Beta-catenin-interacting ICAT; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR026914; Calsyntenin.
DR InterPro; IPR045588; CLSTN_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009428; ICAT_dom.
DR InterPro; IPR036911; ICAT_sf.
DR PANTHER; PTHR14139; CALSYNTENIN; 1.
DR PANTHER; PTHR14139:SF4; CALSYNTENIN-1; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF19699; CLSTN_C; 1.
DR Pfam; PF06384; ICAT; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF81730; beta-catenin-interacting protein ICAT; 1.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50268; CADHERIN_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 927..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..231
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 232..324
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 35..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 122735 MW; E1095DEB09128B1F CRC64;
MTRVLCFRRA APSYFCPATA LPSQLSTCLP EVNFQKQESP EPGRGMNREG APGKSPEEMY
IQQKVRVLLM LRKMGSNLTA SEEEFLRTYA GVVNSQLSQL PPHSIDQVNK HKPWLEPTYH
GIVTENDNAV LLDPPLIALD KDAPLRFAGE ICGFKIHGQN VPFDAVVVDK STGEGVIRSK
EKLDCELQKD YSFTIQAYDC GKGPDGTNVK KSHKATVHIQ VNDVNEYAPV FKEKSYKATV
VEGKQYDSIL RVEAMDADCS PQFSQICSYE IITPDVPFTV DKDGYIKNTE KLNYGKEHQY
KLTVTAYDCG KKRATEDVLV KISVKPTCAP GWQGWNNRIE YEPGTGALAV FPNIHLETCD
EPVASVQATV ELETSHIGKG CDRDTYSEKS LHRLCGAAAG TAELLPSPSG SLNWTVGLPT
DNGHDSDQVF EFNGTQAVRI PDGIVSVNPK EPFTISVWMR HGPFGRKKET ILCSSDKTDM
NRHHYSLYVH GCRLIFLLRQ DPSEEKKYRP AEFHWKLNQV CDEEWHHYVL NVEFPSVTLY
VDGTSHEPFS VTEDYPLHPS KIETQLVVGA CWQEFSGVEN DNETEPVTVA SAGGDLHMTQ
YFRGNLAGLT LRSGKLADKK VIDCLYTCKE GLDLQVPEDS GRGVQIQAHP SQLVLTLEGE
DIGELDKAMQ HISYLNSRQF PTPGIRRLKI TSTIKCFNEA TCISVPPVDG YVMVLQPEEP
KISLSGVHHF ARAASEFESS EGVFLFPELR IISTITREVE PEGDGAEDPT VQESLVSEEI
VHDLDTCEVT VEGEELNHEQ ESLEVDMARL QQKGIEVSSS ELGMTFTGVD TMASYEEVLH
LLRYRNWHAR SLLDRKFKLI CSELSGRYIS NEFKVEVNVI HTANPVEHAN HMAAQPQFVH
PEHRSFVDLS GHNLANPHPF AVVPSTATVV IVVCVSFLVF MIILGVFRIR AAHQRTMRDQ
DTGKENEMDW DDSALTITVN PMEVGVGRRP PRLRGSAGQG LREASMARLL RVHTLSIASS
AQQAWGLGVF MGKPRLREAL FKAVLPTKCG GEPCQGWALL AMGLLREFSG GVAEVLSPAA
LYVGDSMGTH WSFVFPSLLF CCCC
//
