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Database: UniProt
Entry: F7HLZ6_CALJA
LinkDB: F7HLZ6_CALJA
Original site: F7HLZ6_CALJA 
ID   F7HLZ6_CALJA            Unreviewed;      2705 AA.
AC   F7HLZ6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSCJAP00000029049};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSCJAP00000029049};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000029049, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000029049, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000029049}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   STRING; 9483.ENSCJAP00000029049; -.
DR   Ensembl; ENSCJAT00000030696; ENSCJAP00000029049; ENSCJAG00000015544.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   InParanoid; F7HLZ6; -.
DR   OMA; PRHAPYK; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2230   2252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2264   2282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2351   2376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2396   2418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2526   2549       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       91    145       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      152    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    399       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1566   1586       {ECO:0000256|SAM:Coils}.
FT   COILED     2643   2684       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2705 AA;  308561 MW;  FF6172F2921389EE CRC64;
     VDEICLSEKS GGAQSLKKRY TLNSNFFLFA SLLDCLFKLC PMNRYSAQKQ FWKAAKPGAN
     STTDAVLLNK LHHAADLEKK QNETENRKLL GTVIQYGNVI QLLHLKSNKY LTVNKRLPAL
     LEKNAMRVTL DEAGNEGSWF YIQPFYKLRS IGDSVVIGDK VVLNPVNAGQ PLHASSHQLV
     DNPGCNEVNS VNCNTSWKIV LFMKWSDNKD DILKGGDVVR LFHAEQEKFL TCDEHRKKQH
     VFLRTTGRQS ATSATSSKAL WEVEVVQHDP CRGGAGYWNS LFRFKHLATG HYLAAEVDPD
     QDASRSRLRN AQEKMVYSLV SVPEGNDISS IFELDPTTLR GGDSLVPRNS YVRLRHLCTN
     TWVHSTNIPI DKEEEKPVML KIGTSPVKED KEAFAIVPVS PAEVRDLDFA NDASKVLGSI
     AGKLEKGTIT QNERRSVTKL LEDLVYFVTG GTNSGQDVLE VVFSKPNRER QKLMREQNIL
     KQIFKLLQAP FTDCGDGPML RLEELGDQRH APFRHICRLC YRVLRHSQQD YRKNQEYIAK
     QFGFMQKQIG YDVLAEDTIT ALLHNNRKLL EKHITAAEID TFVSLVRKNR EPRFLDYLSD
     LCVSMNKSIP VTQELICKAV LNPTNADILI ETKLVLSRFE FEGVSSTGEN ALEAGEDEEE
     VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY QLNLFARMCL DRQYLAINEI
     SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ EQVTPVKYAR LWSEIPSEIA
     IDDYDSSGAS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS DKEKNKLTFE VVNLARNLIY
     FGFYNFSDLL RLTKILLAIL DCVHVTTIFP ISKMAKGEEN KGNNDVEKLK SSNVMRSIHG
     VGELMTQVVL RGGGFLPMTP MAAAPEGNVK QAEPEKEDIM VMDTKLKIIE ILQFILNVRL
     DYRISCLLCI FKREFDESNS QTSETSSGNS SQEGPSNVPG ALDFEHIEEQ AEGIFGGRKE
     NTPLDLDDHG GRTFLRVLLH LTMHDYPPLV SGALQLLFRH FSQRQEVLQA FKQVQLLVTS
     QDVDNYKQIK QDLDQLRSIV EKSELWVYKG QGPDETMDGA SGENEHKKTE EGNKPQKHES
     TSSYNYRVVK EILIRLSKLC VQESASVRKS RKQQQRLLRN MGAHAVVLEL LQIPYEKAED
     TKMQEIMRLA HEFLQNFCAG NQQNQALLHK HINLFLNPGI LEAVTMQHIF MNNFQLCSEI
     NERVVQHFVH CIETHGRNVQ YIKFLQTIVK AEGKFIKKCQ DMVMAELVNS GEDVLVFYND
     RASFQTLIQM MRSERDRMDE NSPLMYHIHL VELLAVCTEG KNVYTEIKCN SLLPLDDIVR
     VVTHEDCIPE VKIAYINFLN HCYVDTEVEM KEIYTSNHMW KLFENFLVDI CRACNNTSDR
     KHADSILEKY VTEIVMSIVT TFFSSPFSDQ STTLQTRQPV FVQLLQGVFR VYHCNWLMPS
     QKASVESCIR VLSDVAKSRA IAIPVDLDSQ VNNLFLKSHN IVQKTALNWR LSARNAARRD
     SVLAASRDYR NIIERLQDIV SALEDRLRPL VQAELSVLVD VLHRPELLFP ENTDARRKCE
     SGGFICKLIK HTKQLLEENE EKLCIKVLQT LREMMTKDRG YGEKVLRFIF LQELEPSPPL
     RQLEDHKRGE ALRQILVNRY YGNIRPSGRR ESLTSFGNGP LSPGGPSKPG GGGGGSGSSS
     VSRGEMSLAE VQCHLDKEGA SNLVIDLIMN ASSDRVFHES ILLAIALLEG GNTTIQHSFF
     CRLTEDKKSE RFFKVFYDRM KVAQQEIKAT VTVNTSDLGN KKKDDEVDRD APSRKKAKEP
     TTQITEEVRD QLLEASAATR KAFTTFRREA DPDDHYQSGE GTQATADKTK DDLEMSAVIT
     IMQPILRFLQ LLCENHNRDL QNFLRCQNNK TNYNLVCETL QFLDCICGST TGGLGLLGLY
     INEKNVALIN QTLESLTEYC QGPCHENQNC IATHESNGID IITALILNDI NPLGKKRMDL
     VLELKNNASK LLLAIMESRH DSENAERILY NMRPKELVEV IKKAYMQGEV EFEDGENGED
     GASPRNVGHN IYILAHQLAR HNKELQSMLK PGGQVDGDEA LEFYAKHTAQ IEIVRLDRTM
     EQIVFPVPSI CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN WQKKLRAQPV
     LYWCARNMSF WSSISFNLAV LMNLLVAFFY PFKGVRGGTL EPHWSGLLWT AMLISLAIVI
     ALPKPHGIRA LIASTILRLI FSVGLQPTLF LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA
     MVLDVEFLYH LLYLVICAMG LFVHEFFYSL LLFDLVYREE TLLNVIKSVT RNGRSIILTA
     VLALILVYLF SIVGYLFFKD DFILEVDRLP NETTVPETGE SLASEFLFSD MCRVETGENC
     SSPAPKEELV PAEETEEDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA
     RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT
     VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIKERNLDWF PRMRAMSLVS
     SDSEGEQNEL RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN
     PQQPA
//
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