ID F7HP69_MACMU Unreviewed; 1187 AA.
AC F7HP69;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 3 {ECO:0000313|Ensembl:ENSMMUP00000029058.4};
GN Name=IQSEC3 {ECO:0000313|Ensembl:ENSMMUP00000029058.4,
GN ECO:0000313|VGNC:VGNC:73679};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000029058.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000029058.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000029058.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR AlphaFoldDB; F7HP69; -.
DR SMR; F7HP69; -.
DR STRING; 9544.ENSMMUP00000029058; -.
DR Ensembl; ENSMMUT00000031044.4; ENSMMUP00000029058.4; ENSMMUG00000022067.4.
DR VEuPathDB; HostDB:ENSMMUG00000022067; -.
DR VGNC; VGNC:73679; IQSEC3.
DR eggNOG; KOG0931; Eukaryota.
DR GeneTree; ENSGT00940000155908; -.
DR HOGENOM; CLU_004328_2_0_1; -.
DR InParanoid; F7HP69; -.
DR OMA; QPCLARM; -.
DR TreeFam; TF323811; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000022067; Expressed in primary visual cortex and 10 other cell types or tissues.
DR ExpressionAtlas; F7HP69; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd14686; bZIP; 1.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF318; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 649..842
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 62..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 22..56
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 64..78
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1094
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1166
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 128063 MW; 0712175683281001 CRC64;
MESLLENPVR AVLYLKELTA IVQNQQSLIH TQRERIDELE RRLDELSAEN RSLWEHQQLL
QAQPPPGLVP PSSAPLPAAP AASPAAAARA QEPLQDQGQR SAAAPQPAPE LPPLQHHGQL
LEQPQRGPGS RAHTPQSPHK HLGTQGAVTD KEKERPPSCC AAAGALLQHK SPSALGKGVL
SRRPENETVL HQFCCPAADA EQKPACSDLA SHSDGSCTQA SGGMEDSVVA AAAVAAGRPS
AHAPKAQAQE LQEEEERPGA GAASPRAGPQ HMASPGRQQP ALATALCSHT PAASDYELSL
DLKNKQIEML EHKYGGHLVS RRAACTIQTA FRQYQLSKNF EKIRNSLLES RLPRRISLRK
VRAPTAESLA AEKALMEGYG LMGLPLVRAP SLPPTFAGTL TELEDSFTEQ VQSLAKSIDD
ALSTWSLKTM CSLQETGAYQ LHRALQAAAG PPGLEGEMRE PESAGPGPGD EAAETPGLPP
GHSGTLMMAF RDVTVQIASQ NISVSSATAL SVANCLGAQT AQATAEPAAG KAEQGGTPGQ
EAAEAPAVGR GDASAEDSGT EAGAGGAVDE ATAAKAEEEE EEEEAADVGK GAEAEAGDLE
QLSSSSTSTK SAKSGSEVSA SASKDALQAM ILSLPRYHCE NPASCKSPTL STDTLRKRLY
RIGLNLFNIN PDKGIQFLIS RGFIPDTPIG VAHFLLQRKG LSRQMIGEFL GNSKKQFNRD
VLDCVVDEMD FSSMELDEAL RKFQAHIRVQ GEAQKVERLI EAFSQRYCMC NPEVVQQFHN
PDTIFILAFA IILLNTDMYS PNIKPDRKMM LEDFIRNLRG VDDGADIPRE LVVGIYERIQ
QKELKSNEDH VTYVTKVEKS IVGMKTVLSV PHRRLVCCSR LFEVTDVNKL QKQAAHQREV
FLFNDLLVIL KLCPKKKSSS TYTFCKSVGL LGMQFHLFEN EYYSHGITLV TPLSGSERKQ
VLHFCALGSD EMQKFVEDLK ESIAEVTELE QIRIEWELEK QQGTKTLSFK PSGAQGDPQS
KQGSPTAKRE AALREKPAES TVEVSIHNRL QTSQHNSGLG AERGAPVPPP DLPPSPLRQQ
PPPLPPPPPT PPGTLVQCQQ IVKVIVLDKP CLARMEPLLS QALSCYTSSS SDSCGSTPLG
GPGSPVKVIH QPPLPPPPPP YNHPHQFCPP GSLLHRRRYS SGSRSLV
//
