ID F7HRI1_CALJA Unreviewed; 568 AA.
AC F7HRI1; U3C805; U3F665;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Protein NDNF {ECO:0000256|ARBA:ARBA00024096};
GN Name=NDNF {ECO:0000313|EMBL:JAB14972.1,
GN ECO:0000313|Ensembl:ENSCJAP00000005691.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000005691.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000005691.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB14972.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus {ECO:0000313|EMBL:JAB14972.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000005691.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; GAMS01008164; JAB14972.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000005691; -.
DR Ensembl; ENSCJAT00000005998.4; ENSCJAP00000005691.3; ENSCJAG00000003128.4.
DR eggNOG; KOG4806; Eukaryota.
DR GeneTree; ENSGT00390000007586; -.
DR HOGENOM; CLU_041753_0_0_1; -.
DR OMA; KFCIYRK; -.
DR TreeFam; TF313245; -.
DR Proteomes; UP000008225; Chromosome 3.
DR Bgee; ENSCJAG00000003128; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0021828; P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR GO; GO:0061042; P:vascular wound healing; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019326; NDNF.
DR InterPro; IPR045805; NDNF_C.
DR PANTHER; PTHR14619; NEURON-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR14619:SF1; PROTEIN NDNF; 1.
DR Pfam; PF10179; NDNF; 1.
DR Pfam; PF19433; NDNF_C; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..568
FT /note="Protein NDNF"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197473"
FT DOMAIN 174..325
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|SMART:SM00060"
FT DOMAIN 445..554
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|SMART:SM00060"
SQ SEQUENCE 568 AA; 64607 MW; 833B328C837ADB12 CRC64;
MLLLHWCLLW LLFPLSSRTQ KLPTRDEELF QMQIRDKAFF HDSSVIPDGA EISSYLFRDT
PKRYFFVVEE DNTPLSVTVT PCDAPLEWKL SLQELPEDTS GEASGDLEPL EQQKQQIISE
EGTELFSYKG NDVEYFISSS SPSGLYQLDL LSTEKDTHFK IYATTTPESD QPYPELPYDP
RVDVTSLGRT TVTLAWKPSP TASLLKQPIQ YCVVINKEHN FKSLCAVEAK LSADDAFMMA
PKPGLDFSPF DFAHFGFPSD NLGKERGFQA KPSPKLGRHV YSRPKVDIQK ICIGNKNIFT
VSDLKPDTQY YFDVFVVNIN SNMSTAYVGT FARTKEEAKQ KTVELKDGKV TDVFVKRKGA
KILRFAPVSS HQKVTFFIHS CLDAVQIQVR RDGKLLLSQN VEGIRQFQLR GKPKAKYLIR
LKGNKKGASM LKILATTRPT KQAFPSLPED TRIKAFDKLR TCSSATVAWL GTQERNKFCI
YKKEVDDNYN EDQKKREQNQ CLGPDIRKKS EKVLCKYFHS QNLQKAVTTE TIKGLQPGKS
YLLDVYVIGH GGHSVKYQSK VVKTRKFC
//
