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Database: UniProt
Entry: F7HT61_MACMU
LinkDB: F7HT61_MACMU
Original site: F7HT61_MACMU 
ID   F7HT61_MACMU            Unreviewed;      1946 AA.
AC   F7HT61;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   12-SEP-2018, entry version 43.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|Ensembl:ENSMMUP00000017052};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017052, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000017052, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017052,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000017052}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017052};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; JSUE03045539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000018214; ENSMMUP00000017052; ENSMMUG00000008618.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000006718; Chromosome X.
DR   Bgee; ENSMMUG00000008618; Expressed in 12 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; F7HT61; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     95    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    325    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    358    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    534    551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    571    591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    655    674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    724    746       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    861       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    901       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    913    939       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    959    988       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1084   1111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1162   1183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1195   1214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1297   1315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1388   1412       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1546   1580       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      773    796       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1946 AA;  217238 MW;  38FBB5229C89F59B CRC64;
     RSEFLHIDTT PEPSPANGAG PGPEWGLFPG PPAVEGESSG ASGLGTPKRR NQHSKHKTVA
     VASAQRSPRA LFCLTLANPL RRSCISIVEW KPFDILILLT IFANCVALGV YIPFPEDDSN
     TANHNLEQVE YVFLVIFTVE TVLKIVAYGL VLHPSAYIRN GWNLLDFIIV VVGLFSVLLE
     QGPGRPGDAP HTGGKPGGFD VKALRAFRVL RPLRLVSGVP TDPALISAYP SLPAVLNSIM
     KALVPLLHIA LLVLFVIIIY AIIGLELFLG RMHKTCYFLG SDLEAEEDPS PCASSGSGRA
     CTLNQTECRG RWPGPNGGIT NFDNFFFAML TVFQCVTMEG WTDVLYWMQD AMGYELPWVY
     FVSLVIFGSF FVLNLVLGVL SGEFSKEREK AKARGDFQKQ REKQQMEEDL RGYLDWITQA
     EELDMEDPSG RAGHRRQLQS GPQLTELTNR RRGRLRWFSH STRSTHSTSS HASLPASDTG
     SMTETQGDED EEEGALASCT RCLNKIMKTR VCRRLRRANR VLRARCRRAV KSNACYWAVL
     LLVFLNTLTI ASEHHGQPVW LTQIQESTAN KVLLCLLHRG VLLKAYVWPL WLMSSFFNRL
     TASVSVGASW KTPGGATSSG HGIDPSASHF CCRHWASLSN LVASLLNSMK SIASLLLLLF
     LFIIIFSLLG MQLFGGKFNF DQTHTKRSTF DTFPQALLTV FQILTGEDWN VVMYDGIMAY
     GGPFFPGMLV CIYFIILFIC GNYILLNVFL AIAVDNLASG DAGTVPGVEK EEEEGTRREG
     ADMEEEEEEE EEEEEEGAGG VELLQEVVPK EKVVPIPEGS AFFCLSQTNP LRKGCHTLIH
     HHVFTNLILV FIILSSVSLA AEDPIRAHSF RNHILGYFDY AFTSIFTVEI LLKMTVFGAF
     LHRGSFCRSW FNMLDLLVVS VSLISFGIHS SAISVVKILR VLRVLRPLRA INRAKGLKHV
     VQCVFVAIRT IGNIMIVTTL LQFMFACIGV QLFKGKFYTC TDEAKHTPQE CKGSFLVYPD
     GDVSRPLVRE RLWVNSDFNF DNVLSAMMAL FTVSTFEGWP ALLYKAIDAY AEDHGPIYNY
     RVEISVFFIV YIIIIAFFMM NIFVGFVIIT FRAQGEQEYQ NCELDKNQRQ CVEYALKAQP
     LRRYIPKNPH QYRVWATVNS AAFEYLMFLL ILLNTVALAM QHYEQTAPFN YAMDILNMVF
     TGLFTIEMVL KIIAFKPKHY FTDAWNTFDA LIVVGSVVDI AVTEVNNGGH LGESSEDSSR
     ISITFFRLFR VMRLVKLLSK GEGIRTLLWT FIKSFQALPY VALLIAMIFF IYAVIGMQMF
     GKVALQDGTQ INRNNNFQTF PQAVLLLFRC ATGEAWQEIM LASLPGNRCD PESDFGPGEE
     FTCGSNFAIA YFISFFMLCA FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFKRIWSEY
     DPGAKGHIKH LDVVALLRRI QPPLGFGKLC PHRVACKRLV AMNMPLNSDG TVTFNATLFA
     LVRTSLKIKT EGNLEQANQE LRIVIKKIWK RMKQKLLDEV IPPPDEEEVT VGKFYATFLI
     QDYFRKFRRR KEKGLLGNEA APSTSSALQA GLRSLQDLGP EMRQALTCEE EEEEGQEGVE
     EEDEKDLETN KATMVSQPPS RRGSRISVSL PVGDRLPDSL SLGPSDDDRG TPTSSQPSVP
     QAGSNTHRRG SGALIFTIPE EGNSQPKGTR GQDKQDEDEE VPDRLSYLDE QAGTPPYPVL
     LPPHRAQRYM DGHLAPRRRL LPPTPAGRKP SFTIQCLQRQ GSCEDLPIPG TYHRGRNSGP
     NRAQGSWATP PQRGRLLYAP LLLVEEGAAG EGYLGRSSGP LRTFTCLHVP GTHSDPSHGK
     RGSADSLVEA VLISEGLGLF ARDPRFVALA KQEIADACRL TLDEMDSAAS DLLAQGTSSL
     YSDEESILSR FDEEDLGDEM ACVHAL
//
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