ID F7HVB6_CALJA Unreviewed; 97 AA.
AC F7HVB6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Neuropeptide Y {ECO:0000313|EMBL:JAB20790.1, ECO:0000313|Ensembl:ENSCJAP00000054614.1};
GN Name=NPY {ECO:0000313|EMBL:JAB20790.1,
GN ECO:0000313|Ensembl:ENSCJAP00000054614.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000054614.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000054614.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB20790.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB25820.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB20790.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000054614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC of gonadotrophin-release hormone. {ECO:0000256|ARBA:ARBA00037434}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, neuronal
CC dense core vesicle {ECO:0000256|ARBA:ARBA00037849}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000256|ARBA:ARBA00010022,
CC ECO:0000256|RuleBase:RU000656}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01002346; JAB20790.1; -; mRNA.
DR EMBL; GAMR01008112; JAB25820.1; -; mRNA.
DR RefSeq; XP_002751528.1; XM_002751482.3.
DR Ensembl; ENSCJAT00000079101.3; ENSCJAP00000054614.1; ENSCJAG00000078083.1.
DR GeneID; 100385471; -.
DR KEGG; cjc:100385471; -.
DR CTD; 4852; -.
DR eggNOG; ENOG502S2BU; Eukaryota.
DR GeneTree; ENSGT00940000156475; -.
DR HOGENOM; CLU_162379_1_0_1; -.
DR OrthoDB; 4180655at2759; -.
DR TreeFam; TF332778; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000040907; Expressed in frontal cortex and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0098992; C:neuronal dense core vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR Gene3D; 6.10.250.900; -; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY; 1.
DR PANTHER; PTHR10533:SF5; PRO-NEUROPEPTIDE Y; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 2: Evidence at transcript level;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Neuropeptide {ECO:0000313|EMBL:JAB20790.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..97
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015091263"
SQ SEQUENCE 97 AA; 10883 MW; F522076F998500B5 CRC64;
MLGSKRLGLS GLTLILSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT
RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPSMW
//
