ID F7HWF5_CALJA Unreviewed; 1983 AA.
AC F7HWF5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSCJAP00000031068.5};
GN Name=DOCK4 {ECO:0000313|Ensembl:ENSCJAP00000031068.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031068.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000031068.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000031068.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9483.ENSCJAP00000031068; -.
DR Ensembl; ENSCJAT00000032832.5; ENSCJAP00000031068.5; ENSCJAG00000016740.6.
DR GeneTree; ENSGT00940000155659; -.
DR InParanoid; F7HWF5; -.
DR OMA; MRDFGHS; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000016740; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11705; DHR2_DOCK4; 1.
DR CDD; cd12049; SH3_DOCK4_B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037014; DHR2_DOCK4.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR035769; DOCK4_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 403..576
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1201..1607
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1660..1740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1477..1504
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1660..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1713..1727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1768..1787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1887..1903
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1983 AA; 227070 MW; 14FCD242D9C7162E CRC64;
MDMIAFIYSV SFFTVIASFR GTVPYGLSLE IGDTVQILEK CDGWYRGFAL KNPNIKGIFP
SSYVHLKNAC VKNKGQFEMV IPTEDSVITE MTSTLRDWGT MWKQLYVRNE GDLFHRLWHI
MNEILDLRRQ VLVGHLTHDR MKDVKRHITA RLDWGNEQLG LDLVPRKEYA MVDPEDISIT
ELYRLMEHRH RKKDTPVQAS SHHLFVQMKS LMCSNLGEEL EVIFSLFDSK ENRPISERFF
LRLNRNGLPK APDKPERHCS LFVDLGSSEL RKDIYITVHI IRIGRMGAGE KKNACSVQYR
RPFGCAVLSI ADLLTGETKD DLILKVYMCN TESEWYQIHE NIIKKLNARY NLTGSNAGLA
VSLQLLHGDI EQIRREYSSV FSHGVSITRK LGFSNIIMPG EMRNDLYITI ERGEFEKGGK
SVARNVEVTM FIIDSSGQTL KDFISFGSGE PPASEYHSFV LYHNNSPRWS ELLKLPIPVD
KFRGAHIRFE FRHCSTKEKG EKKLFGFSFV PLMQEDGRTL PDGTHELIVH KCEENTNLQD
TTRYLKLPFS KGIFLGNNNQ AMKATKESFC ITSFLCSTKL TQNGDMLDLL KWRTHPDKIT
GCLSKLKEID GSEIVKFLQD TLDTLFGILD ENSQKYGSKV FDSLVHIINL LQDSKFHHFK
PVMDTYIESH FAGALAYRDL IKVLKWYVDR ITEAERQEHI QEVLKAQEYI FKYIVQSRRL
FSLATGGQNE EEFRCCIQEL LMSVRFFLSQ ESKGSGALSQ SQAVFLSSFP AVYSELLKLF
DVREVANLVQ DTLGSLPTIL HVDDSLQAIK LQCIGKTVES QLYTNPDSRY ILLPVVLHHL
HIHLQEQKDL IMCARILSNV FCLIKKNSSE KSVLEEIDVI VTSLLDILLR TILEITSRPQ
PSSSAMRFQF QDVTGEFVAC LLSLLRQMTD RHYQQLLDSF NSKEELRDFL LQIFTVFRIL
IRPEMFPKDW TVMRLVANNV IITTVLYLSD ALRKNFLNEN FDYKIWDSYF YLAVIFINQL
CLQLEMFTPS KKKKVLEKYG DMRVTMGCEI FSMWQNLGEH KLHFIPALIG PFLEVTLIPQ
PDLRNVMIPI FHDMMDWEQR RSGNFKQVEA KLIDKLDSLM SEGKGDETYR ELFNSIIPLF
GPYPSLLKKI ERETWRESGV SLIATVTRLM ERLLDYRDCM KMGEVDGKKI GCTVSLLNFY
KTELNKEEMY IRYIHKLYDL HLKAQNFTEA AYTLLLYDEL LEWSDRPLRE FLTYPMQTEW
QRKEHLHLTI IQNFDRGKCW ENGIILCRKI AEQYESYYDY RNLSKMRMME ASLYDKIMDQ
QRLEPEFFRV GFYGKKFPFF LRNKEFVCRG HDYERLEAFQ QRMLNEFPHA IAMQHANQPD
ETIFQAEAQY LQIYAVTPIP ESQEVLQREG VPDNIKSFYK VNHIWKFRYD RPFHKGTKDK
ENEFKSLWVE RTSLYLVQSL PGISRWFEVE KREVVEMSPL ENAIEVLENK NQQLKTLISQ
CQTRQMQNIN PLTMCLNGVI DAAVNGGVSR YQEAFFVKEY ILSHPEDGEK IARLRELMLE
QAQILEFGLA VHEKFVPQDM RPLHKKLVDQ FFVMKSSLGI QEFSACMQAS PIHFPNGSPR
VCRNSAPASV SPDGTRVIPR RSPLSYPAVN RYSSSSLSSQ ASAEVSNITG QSESSDEVFN
MQPSPSTSSL SSTHSASPNV TSSAPSSARA SPLLSDKHKH SRENSCLSPR ERPCSAIYPT
PVEPSQRMLF NHIGDGALPR SDPNLSAPEK AVNPTPSSWS LDSGKEAKNM SDSGKLISPP
VPPRPTQTAS PARHTTSISP SPAGRSPLKG SVQSFTPSPV EYHSPGLISN SPVLSGSYSS
GISSLSRCST SETSGFENQV NEQSAPMPVP VPVPVPVPVP VPTYSGEEPV RKESKTPPPY
SVYERTLRRP VPLPHSLSIP VTSEPPALPP KPLAARSSHL ENGARRTDPG PRPRPLPRKV
SQL
//
