ID F7HX66_CALJA Unreviewed; 1032 AA.
AC F7HX66;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Toll-like receptor 9 {ECO:0000256|ARBA:ARBA00017400};
GN Name=TLR9 {ECO:0000313|Ensembl:ENSCJAP00000011186.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011186.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000011186.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000011186.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; F7HX66; -.
DR STRING; 9483.ENSCJAP00000011186; -.
DR Ensembl; ENSCJAT00000011805.5; ENSCJAP00000011186.2; ENSCJAG00000006069.5.
DR GeneTree; ENSGT00940000162493; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; F7HX66; -.
DR OMA; YNQNFCR; -.
DR Proteomes; UP000008225; Chromosome 15.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0032009; C:early phagosome; IEA:Ensembl.
DR GO; GO:0036019; C:endolysosome; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1902350; P:cellular response to chloroquine; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0032490; P:detection of molecule of bacterial origin; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IEA:Ensembl.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032741; P:positive regulation of interleukin-18 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:1905300; P:positive regulation of intestinal epithelial cell development; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0034165; P:positive regulation of toll-like receptor 9 signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0045577; P:regulation of B cell differentiation; IEA:Ensembl.
DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0034162; P:toll-like receptor 9 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF3; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 19.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 868..1013
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1032 AA; 115376 MW; CBB52784A9DDB495 CRC64;
MGFCRSTLHP LSILVQAMVL AMTLALGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSVAA
PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR RLDLKWNCPP VGLSPMHFPC HMTIEPNTFL
AVPTLEELNL SYNSITAVPA LPKSLVSLTL SRTNILVLDS ASLAGLHALR FLFMDGNCYY
KNPCREALEV APGALLGLGN LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN HIIKLAPGDL
ANLTALRGLD VGGNCRRCDH APNPCLECPR HFPQLHPNTF SHLSRLEGLV LKDSSLSWLN
ASWFHGLGNL RVLDLSENFL YECITKTKAF QGLTQLRKLN LSFNYQKRVS FAHLSLAPSF
GSLFSLEELD MHGIFFRSLD ETTLRPLARL SRLQTLHLQM NFINQAQLDI FGSFPGLRHV
DLSDNRISGA SELAATTGEA DGGEKVWLQP GDLAPAPVDT PSSEDFMANC GTLNFTLDLS
RNNLVTVRPE MFARLSHLQC LRLSHNCITQ AVNGSQFLPL TDLRVLDLSH NKLDLYHEHS
FTELPRLEAL DLSYNSQPFG MQGVGHNFSF VAHLRTLRYL SLAHNNIHSR VSSQLCSTSL
RALDFSGNAL GRMWAEGDLY LHFFQGLSGL IWLDLSQNSL HTLLPRTLGN LPKTLQVLRL
RDNKLAFFKW KSLALLSKLE ALDLAGNQLK ALTNGSLPAM TRLRKLDISS NSISFVAPGF
FSNAKKLREL NLSANALKTV DPSWFGPLVG ALKILDVSTN PLHCACGAAF VDFLLEVQAA
VPGLPSRVRC GSPAQLQGQS IFAQDLRLCL DEALSRDCFS LSLLAVALGL GVPLLHQLCG
WDLWYCFYLG LAWLPRWGRR GGRGEDALPY DAFVVFDKAQ SAVADWVYNE LRRQLEERRG
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS FLLAQQRLLE
DRKDVVVLVI LSPEAHRSRY VRLRQRLCRQ SVLLWPNQPS GQRSFWAQLG IALTRDNHHF
YNRNFCQGPT TE
//
