ID F7HY80_CALJA Unreviewed; 186 AA.
AC F7HY80;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial {ECO:0000256|ARBA:ARBA00020530, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=Complex I-ASHI {ECO:0000256|ARBA:ARBA00032752, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit {ECO:0000256|ARBA:ARBA00032699, ECO:0000256|PIRNR:PIRNR009288};
GN Name=NDUFB8 {ECO:0000313|Ensembl:ENSCJAP00000031928.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000031928.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000031928.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000031928.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC {ECO:0000256|ARBA:ARBA00008039, ECO:0000256|PIRNR:PIRNR009288}.
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DR RefSeq; XP_009008404.1; XM_009010156.2.
DR AlphaFoldDB; F7HY80; -.
DR STRING; 9483.ENSCJAP00000031928; -.
DR Ensembl; ENSCJAT00000033747.4; ENSCJAP00000031928.1; ENSCJAG00000037906.4.
DR GeneID; 100415640; -.
DR KEGG; cjc:100415640; -.
DR CTD; 4714; -.
DR eggNOG; KOG4040; Eukaryota.
DR GeneTree; ENSGT00390000000628; -.
DR HOGENOM; CLU_108654_1_0_1; -.
DR InParanoid; F7HY80; -.
DR OMA; PRYKNSY; -.
DR OrthoDB; 2940624at2759; -.
DR TreeFam; TF317319; -.
DR Proteomes; UP000008225; Chromosome 12.
DR Bgee; ENSCJAG00000037906; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:UniProtKB-UniRule.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:UniProtKB-UniRule.
DR InterPro; IPR008699; NDUFB8.
DR InterPro; IPR016551; Ndufb8_metazoa.
DR PANTHER; PTHR12840:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12840; NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT; 1.
DR Pfam; PF05821; NDUF_B8; 1.
DR PIRSF; PIRSF009288; NDUB8; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|PIRNR:PIRNR009288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR009288};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Respiratory chain {ECO:0000256|PIRNR:PIRNR009288};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR009288}.
SQ SEQUENCE 186 AA; 21909 MW; B4FB0D1B5776E628 CRC64;
MAVARAGVLG IRWLQRASRN VVPLGARTAF HLNKDMLPGP YPRTPEERAA AAKKYNMRVE
DYEPYPDDGM GYGDYPKLPD RSQHERDPWY DWDQPDLRLN WGETMHWDID MYTRNRVDTS
PTPISWDDMC KQLFSFVAFM VFMFWVGHKY PVYQPVAPKQ YPYNDLYLER GGNPSEEPKP
VVHYEI
//
