ID   F7HZ86_CALJA            Unreviewed;       937 AA.
AC   F7HZ86;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSCJAP00000034396.5};
GN   Name=SORCS1 {ECO:0000313|Ensembl:ENSCJAP00000034396.5};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000034396.5, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000034396.5}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000034396.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F7HZ86; -.
DR   Ensembl; ENSCJAT00000036328.5; ENSCJAP00000034396.5; ENSCJAG00000018526.5.
DR   GeneTree; ENSGT01030000234563; -.
DR   Proteomes; UP000008225; Chromosome 12.
DR   Bgee; ENSCJAG00000018526; Expressed in cerebellum and 3 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        860..878
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          594..638
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          898..937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        898..917
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   937 AA;  105605 MW;  76C52EB02F759C2F CRC64;
     IMLLTDPEIE SSLLISSDEG ATYQKYRLNF YIQSLLFHPK QEDWILAYSQ DQKLYSSAEF
     GRRWQLIQEG VVPNRFYWSV MGSNKEPDLV HLEARTVDGH SHYLTCRMQN CTEANRNKPF
     PGYIDPDSLI VQDDYVFVQL TSGGRPHYYV SYRRNTFAQM KLPKYALPKD MHVISTDENQ
     VFAAVQEWNQ NDTYNLYISD TRGVYFTLAL ENVQSSRGPE GNVMIDLYEV AGIKGMFLAN
     KKIDNQVKTF ITYNKGRDWR LLQAPDTDLR GDPVHCLLPY CSLHLHLKVS ENPYTSGIIA
     SKDTAPSIIV ASGNIGSELS DTDISMFVSS DAGNTWRQIF EEEHSVLYLD QGGVLVAMKH
     TSLPIRHLWL SFDEGRSWSK YSFTSIPLFV DGVLGEPGEE TLIMTVFGHF SHRSEWQLVK
     VDYKSIFDRR CAEEDYRPWQ LHSQGEACIM GAKRIYKKRK SERKCMQGKY AGAMESKPCV
     CTEADFDCDY GYERHSNGQC LPAFWFNPSS LSKDCSLGQS YLNSTGYRKV VSNNCTDGVR
     EQYTAKPQKC PGKAPRGLRI VTADGKLTAE QGHNVTLMVQ LEEGDVQRTL IQVDFGDGIA
     VSYVNLSSME DGIKHVYQNV GIFRVTVQVD NSLGSDSAVL YLHVTCPLEH VHLSLPFVTT
     KNKEVNATAV LWPSQVGTLT YVWWYGNNTE PLITLEGSIS FRFTSEGMNT ITVQVSAGNA
     ILQDTKTIAV YEEFRSLRLS FSPNLDDYNP DIPEWRRDIG RVIKKSLVEA TGVPGQHILV
     AVLPGLPTTA ELFVLPYQDP AGENKRSADD LEQISELLIH KLNQNSVHFE LKPGVQVLVH
     AAHLTAAPLV DLTPTHSGSA MLMLLSVVFV GLAVFVIYKF KRKIPGINAY AQMQNEKEQE
     MISPVSHSES RPSVPQSELR RPGQLIDEKV ESQLIGE
//