ID F7I1H6_CALJA Unreviewed; 629 AA.
AC F7I1H6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=MAGUK p55 scaffold protein 4 {ECO:0000313|Ensembl:ENSCJAP00000046563.2};
GN Name=MPP4 {ECO:0000313|Ensembl:ENSCJAP00000046563.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000046563.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000046563.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000046563.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; F7I1H6; -.
DR STRING; 9483.ENSCJAP00000046563; -.
DR Ensembl; ENSCJAT00000059642.3; ENSCJAP00000046563.2; ENSCJAG00000004750.6.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000156444; -.
DR HOGENOM; CLU_001715_5_0_1; -.
DR InParanoid; F7I1H6; -.
DR OMA; PACWIRP; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000008225; Chromosome 6.
DR Bgee; ENSCJAG00000004750; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12034; SH3_MPP4; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035600; MPP4_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF34; MAGUK P55 SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 24..80
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 87..137
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 154..228
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 235..305
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 420..609
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 563..614
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 629 AA; 71731 MW; 572AB82792DB161D CRC64;
MIQSDKGADA PDKKDMKLST ATNPQNGLSQ ILRLVLQELS LFYSRDVNGV CLLYDLLHSP
WLQALLKIYD CLQEFKEKKL VPATPHAQAL SYEVVELLRE TPSSSEIQEL RQTLQAPHFK
ALLSAHDTIA QKDFEPLLPP LPDNIPESEE AMRIVCLVKN QQPLGATIKR HEMTGDILVA
RVIHGLLYAG DKLVEVNGVS VEGLNPEQVI HILAMSRGTI MFKVVPVSDP PVNSQKMVYV
RAMTEYWPQE DPDIPCMDAG LPFQKGDILQ IVDQNDALWW QARKISDPAT CAGLVPSNHL
LKRKQREFWW SQPYQPHTCL KSTLSISMEE EDDMKIDEKC VEADEETFES EELSEDKEEF
VGYGQKFFIA GFRHSMRLCR RKSHVSPLHA SVCCNGSCYS AVGAPYEEVV KYQRRPSDKY
RLIVLVGPSG VGVNELRRQL IEFNPSHFQS AVPHTTRTKK SYEMNGREYH YVSKETFESL
IYSHRMLEHG EYKGHLYGTS ADAVQTVLDE GKVCVMDLEP QDIQVARTHE LKPYVIFIKP
SNMRCMKQSR KNAKIITDYF VDMKFKDEDL QEMENLAQRM ETQFGQFFDH VIVNDSLQDA
CAQLLSAIQK AQEEPQWVPA TWISSDTES
//
