ID F7I3B6_CALJA Unreviewed; 410 AA.
AC F7I3B6; U3EG12;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Neuroserpin {ECO:0000313|EMBL:JAB49843.1};
DE SubName: Full=Serpin family I member 1 {ECO:0000313|Ensembl:ENSCJAP00000005004.3};
GN Name=SERPINI1 {ECO:0000313|EMBL:JAB49843.1,
GN ECO:0000313|Ensembl:ENSCJAP00000005004.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000005004.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000005004.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB49843.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB49843.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000005004.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; GAMP01002912; JAB49843.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000005004; -.
DR MEROPS; I04.025; -.
DR Ensembl; ENSCJAT00000005273.5; ENSCJAP00000005004.3; ENSCJAG00000002746.5.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000158168; -.
DR HOGENOM; CLU_023330_0_4_1; -.
DR OMA; IQNGFHV; -.
DR TreeFam; TF352620; -.
DR Proteomes; UP000008225; Chromosome 17.
DR Bgee; ENSCJAG00000002746; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0034774; C:secretory granule lumen; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR CDD; cd02048; serpinI1_NSP; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF50; NEUROSERPIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..410
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004641899"
FT DOMAIN 31..397
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 410 AA; 46333 MW; 8B74E1B19DF40623 CRC64;
MAFLGLFSLL LLQSMAVGAT LPDEAIADLS VNMYNRLRAT GEDENILFSP LSIALAMGMM
ELGAQGSTQK EIRHSMGYDS LKNGEEFSLL KEFSNMATAK ESQYVMKIAN SLFVQNGFHV
NEEFLQMMKK YFNAEVNHVD FSQNVAVANH INKWVENNTN NLLKDLVSPR DFDAATHLAL
INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ
VLEIPYEGDE IGMMLVLSRQ EVPLATLEPL VKAQLIEEWA NSVKKQKVEV YLPRFTVEQE
IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI
SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM NTSGHDFEEL
//
