ID F7I5H9_CALJA Unreviewed; 2095 AA.
AC F7I5H9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PI4KA {ECO:0000313|Ensembl:ENSCJAP00000029187.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000029187.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000029187.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000029187.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR STRING; 9483.ENSCJAP00000029187; -.
DR Ensembl; ENSCJAT00000030841.5; ENSCJAP00000029187.3; ENSCJAG00000015845.6.
DR GeneTree; ENSGT00550000074798; -.
DR HOGENOM; CLU_011483_1_0_1; -.
DR InParanoid; F7I5H9; -.
DR OMA; TIEVWQS; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000015845; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:Ensembl.
DR GO; GO:0044788; P:modulation by host of viral process; IEA:Ensembl.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0140754; P:reorganization of cellular membranes to establish viral sites of replication; IEA:Ensembl.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1523..1711
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1801..2079
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 250..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2095 AA; 236364 MW; 27C359FF51A8A5D5 CRC64;
MAAAAARGGG GGGGSGSSAS RGFYFNTVLS LARSLAVQRP ASLEKVQKLL CMCPVDFHGI
FQLDERRRDA VIALGIFLIE SDLQHKDCVV PYLLRLLKGL PKVYWVEEST ARKGRGALPV
SESFSFCLIT LLSDVAYRDP SLRDEILEAL LQVLHVLLGM CQALEIQDKE YLCKYAIPCL
IGISRAFGRY SNMEESLLSK LFPKVPPHSL RVPEELEGVR RRSFNDFRSI LPSNLLTVCQ
EGTLKRKTSS VSSISQVSPE RGMPPPSSPG GSAFHYFEAS CLPDGTALEP EYYFSTISSS
FSVSPLFNGV TYKEFNIPLE MLRELLNLVK KIVEEPVLKS LDAIVASVME ANPSADLYYT
SFSDPLYLTM FKMLRDTLYY MKDLPTSFVK EIHDFVLEQF NTSQGELQKI LHDADRIHNE
LSPLKLRCQA NAACVDLMVW AVKDEQGAEN LCIKLSEKLQ SKTSSKVIIA HLPLLICCLQ
GLGRLCERFP VVVHSVTPSL RDFLVIPSPV LVKLYKYHSQ YHTVAGNDIK ISVTNEHSES
TLNVMSGKKS QPSMYEQLRD IAIDNICRCL KAGLTVDPVI VEAFLASLSN RLYISQESDK
DAHLIPDHTI RALGHIAVAL RDTPKVMEPI LQILQQKFCQ PPSPLDVLII DQLGCLVITG
NQYIYQEVWN LFQQISVKAS SVVYSATKDY KDHGYRHCSL AVINALANIA ANIQDEHLVD
ELLMNLLELF VQLGLEGKRA SERASEKGPA LKASSSAGNL GVLIPVIAVL TRRLPPIKEA
KPRLQKLFRD FWLYSVLMGF AVEGSGLWPE EWYEGVCEIA TKSPLLTFPS KEPLRSVLQY
NSAMKNDTVT PAELSELRST IINLLDPPPE VSALINKLDF AMSTYLLSVY RLEYMRVLRS
TDPDRFQVMF CYFEDKAIQK DKSGMMQCVI AVADKVFDAF LNMMADKAKT KENEEELERH
AQFLLVNFNH IHKRIRRVAD KYLSGLVDKF PHLLWSGTVL KTMLDILQTL SLSLSADIHK
DQPYYDIPDA PYRITVPDTY EARESIVKDF AARCGMILQE AMKWAPTVTK SHLQEYLNKH
QNWVSGLSQH TGLAMATESI LHFAGYNKHN TTLGATQLTE RPACVKKDYS SFMASLNLRN
RYAGEVYGMI RFSGTTGQMS DLNKMMVQDL HSALDHSHPQ HYTQAMFKLT AMLISSKDCD
PQLLHHLCWA PLQMFNEHGM ETALACWEWL LAGKDGVEVP FMREMAGAWH MTVEQKFGLF
SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV EIFSSLLQRS
MSLNIGGAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK IYSTAFDYFS
CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPDNQDTRSN LDITVGSRQQ
ATQGWINTYP LSSGMSTISK KSGMSKKTNR GSQLHKYYMK RRTLLLSLLA TEIERLITWY
NPLSAPELEL DQAGENSVAN WRSKYISLSE KQWKDNVNLA WSISPYLAVQ LPARFKNTEA
IGNEVTRLVR LDPGAVSDVP EAIKFLVTWH TIDADAPELS HVLCWAPTDP PTGLSYFSSM
YPPHPLTAQY GVKVLRSFPP DAILFYIPQI VQALRYDKMG YVREYILWAA SKSQLLAHQF
IWNMKTNIYL DEEGHQKDPD IGDLLEQLVE EITGSLSGPA KDFYQREFDF FNKITNVSAI
IKPYPKGDER KKACLSALSE VKVQPGCYLP SNPEAIVLDI DYKSGTPMQS AAKAPYLAKF
KVKRCGVSEL EKEGLRCRSD SEDECGMQET DSQKISWQAA IFKVGDDCRQ DMLALQIIDL
FKNIFQLVGL DLFVFPYRVV ATAPGCGVIE CIPDCTSRDQ LGRQTDFGMY DYFTRQYGDE
STLAFQQARY NFIRSMAAYS LLLFLLQIKD RHNGNIMLDK KGHIIHIDFG FMFESSPGGN
LGWEPDIKLT DEMVMIMGGK MEATPFKWFM EMCVRGYLAV RPYMDAVVSL VTLMLDTGLP
CFRGQTIKLL KHRFSPNMTE REAANFIMKV IQSCFLSNRS RTYDMIQYYQ NDIPY
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