ID F7I610_CALJA Unreviewed; 821 AA.
AC F7I610;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Rho GTPase activating protein 44 {ECO:0000313|Ensembl:ENSCJAP00000008485.4};
GN Name=ARHGAP44 {ECO:0000313|Ensembl:ENSCJAP00000008485.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000008485.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000008485.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000008485.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7I610; -.
DR Ensembl; ENSCJAT00000008973.4; ENSCJAP00000008485.4; ENSCJAG00000004605.5.
DR GeneTree; ENSGT00940000157296; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000004605; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF13; RHO GTPASE-ACTIVATING PROTEIN 44; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 27..262
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 268..458
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 480..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..750
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 89569 MW; 74C48F3907B3C5DE CRC64;
MQRHDLSSPQ PPPPEFKQFS CLSLPSNWDY RAEKTEVLSE DLLQVEKRLE LVKQVSHSTH
KKLTACLQGQ QGAEADKRSK KLPLTTLAQC LMEGSAILGD DTLLGKMLKL CGETEDKLAQ
ELIHFELQVE RDVIEPLFLL AEVEIPNIQK QRKHLAKLVL DMDSSRTRWQ QTSKSSGLSS
SLQPAGAKAD ALREEMEEAA NRVEICRDQL SADMYSFVAK EIDYANYFQT LIEVQAEYHR
KSLTLLQAVL PQIKAQQEAW VEKPSFGKAL EEHLTISGRE IAFPIEACVT MLLECGMQEE
GLFRVAPSAS KLKKLKAALD CCVVDVQEYS ADPHAIAGAL KSYLRELPEP LMTFELYDEW
IQASNIQEQD KKLQALWNAC EKLPKANHNN IRYLIKFLSK LSEYQDVNKM TPSNMAIVLG
PNLLWPQAEG NITEMMTTVS LQIVGIIEPI IQHADWFFPG EIEFNITGNY GSPVHVNHNA
NYSSMPSPDM DPADRRQPEQ ARRPLSVATD NMMLEFYKKD GMGVRVMDTS WVARRGSSAG
RKASCAPPSM QPPAPPAELA APLPSPLPEQ PLDSPAAPAV SPSGLGLQPG PERTSASKSK
ELSPGSTQKG SPGSSQGTAC AGTQPGPQPG ASPSPSQLPA DQSPHTLRKV SKKLAPIPPK
VPFGQPGAVA DQSAGQPSPV SLSPTPPSTP SPYGLSYPQG YSLASGQLSP AAAPPLASPS
VFTSTLTKSR PTPKPRQRPT LPPPQPPTVN LSASSPQSSE PPMLDGMPPG ESMSTDLVHF
DIPSIHIELG STLRLSPLEH VRRHSVTDKR DSEEESESTA L
//
