ID F7I6A7_CALJA Unreviewed; 781 AA.
AC F7I6A7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=SIX homeobox 4 {ECO:0000313|Ensembl:ENSCJAP00000035525.3};
GN Name=SIX4 {ECO:0000313|Ensembl:ENSCJAP00000035525.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000035525.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000035525.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000035525.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR AlphaFoldDB; F7I6A7; -.
DR STRING; 9483.ENSCJAP00000035525; -.
DR Ensembl; ENSCJAT00000037519.4; ENSCJAP00000035525.3; ENSCJAG00000019133.4.
DR eggNOG; KOG0775; Eukaryota.
DR GeneTree; ENSGT00940000160820; -.
DR HOGENOM; CLU_020633_2_0_1; -.
DR InParanoid; F7I6A7; -.
DR OMA; MCGEMEA; -.
DR OrthoDB; 5317763at2759; -.
DR TreeFam; TF315545; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000019133; Expressed in ovary and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR GO; GO:0061197; P:fungiform papilla morphogenesis; IEA:Ensembl.
DR GO; GO:0048699; P:generation of neurons; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030238; P:male sex determination; IEA:Ensembl.
DR GO; GO:0072075; P:metanephric mesenchyme development; IEA:Ensembl.
DR GO; GO:0051451; P:myoblast migration; IEA:Ensembl.
DR GO; GO:0061055; P:myotome development; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1902725; P:negative regulation of satellite cell differentiation; IEA:Ensembl.
DR GO; GO:0030910; P:olfactory placode formation; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0072107; P:positive regulation of ureteric bud formation; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; IEA:Ensembl.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR GO; GO:0098528; P:skeletal muscle fiber differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0061551; P:trigeminal ganglion development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF36; HOMEOBOX PROTEIN SIX4; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 229..280
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 231..281
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 82888 MW; 3581E2E976C6A174 CRC64;
MSSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA VGLSPPAPAP FPLEPGDAAT
AAARVSGEEG AVAAAAAGEA ADQVQLHSEL LGRHHHAAAA AQTPLAFSPD HVACVCEALQ
QGGNLDRLAR FLWSLPQSDL LRGNESLLKA RALVAFHQGI YPELYSILES HSFESANHPL
LQQLWYKARY TEAERARGRP LGAVDKYRLR RKFPLPRTIW DGEETVYCFK EKSRNALKEL
YKQNRYPSPA EKRHLAKITG LSLTQVSNWF KNRRQRDRNP SETQSKSESD GNPSTEDESS
KGHEDLSPHP LSSSSDGVTN LSLSGHMEPV YMQQIGNAKI SLSSSGVLLN GSLVPASTSP
VFLNGNSFIQ GPSGVILNGL NVGNTQAVAL NPAKMSSNIV SNGISMTDIL GSTSQDVKEF
KVLQSSAANS AATTSYSPSV PVSFPGLIPS TEVKREGIQT VASQDGGSVV TFTTPVQINQ
YGIVQIPNSG ANSQFLNGSI GFSSLQLPPV SVTASQGNIS VSSSTSDGST FTSESATIQQ
GKVFLSSLAP SAVVYTVPNS GQTIGSVKQE GLERSLVFSQ LMPVNQNAQV NANLSSENIS
GSGLHPLASS LVNVSPTHNF SLSPPTLLNP TELNPDIADS QPMSAPVASK STVTSVSNTN
YATLQNCSLI TGQDLMSVPM TQAALGEIVP TAEDQVGHPS PAVHQDFVRE HRLVLQSVAN
MKENFLPNSE SKATSSLMML DSKSKYVLDG MVDTVCEDLE TDKKELAKLQ TVQLDEDMQD
L
//
