ID F7I6W3_CALJA Unreviewed; 358 AA.
AC F7I6W3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Aquaporin-4 {ECO:0000256|ARBA:ARBA00040878};
GN Name=AQP4 {ECO:0000313|Ensembl:ENSCJAP00000038580.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000038580.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000038580.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000038580.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004415}. Cell projection
CC {ECO:0000256|ARBA:ARBA00004316}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR RefSeq; XP_008977889.1; XM_008979641.2.
DR AlphaFoldDB; F7I6W3; -.
DR STRING; 9483.ENSCJAP00000038580; -.
DR Ensembl; ENSCJAT00000040758.5; ENSCJAP00000038580.4; ENSCJAG00000020734.5.
DR GeneID; 100409781; -.
DR CTD; 361; -.
DR GeneTree; ENSGT00940000156037; -.
DR HOGENOM; CLU_020019_3_3_1; -.
DR InParanoid; F7I6W3; -.
DR OMA; PTAMFYW; -.
DR OrthoDB; 3236018at2759; -.
DR Proteomes; UP000008225; Chromosome 13.
DR Bgee; ENSCJAG00000020734; Expressed in cerebellum and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0015250; F:water channel activity; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0050891; P:multicellular organismal-level water homeostasis; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR NCBIfam; TIGR00861; MIP; 1.
DR PANTHER; PTHR19139; AQUAPORIN TRANSPORTER; 1.
DR PANTHER; PTHR19139:SF34; AQUAPORIN-4; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR02016; AQUAPORIN4.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023139};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 21..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 38856 MW; 7D4F2EEC784EF831 CRC64;
MSDRPTARRW GRIDWRKKAS SLSRLPAHHP PPRSSARRDT WSSNPIKCGP LCTRENIMVA
FKGVWTQAFW KAVTAEFLAM LIFVLLSLGS TINWGGTEKP LPVDMVLISL CFGLSIATMV
QCFGHISGGH INPAVTVAMV CTRKISIAKS VFYIAAQCLG AIIGAGILYL VTPPSVVGGL
GVTMVHGNLT AGHGLLVELI ITFQLVFTIF ASCDSKRTDV TGSIALAIGF SVAIGHLFAI
NYTGASMNPA RSFGPAVIMG NWENHWIYWV GPIIGAVLAG GLYEYVFCPD VELKRRFKEA
FSKAAQQTKG SYMEVEDNRS QVETDDLILK PGVVHVIDID RGEEKKGKDQ SGEVLSSV
//