ID F7IB36_CALJA Unreviewed; 871 AA.
AC F7IB36;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rho GTPase activating protein 27 {ECO:0000313|Ensembl:ENSCJAP00000023505.2};
GN Name=ARHGAP27 {ECO:0000313|Ensembl:ENSCJAP00000023505.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023505.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000023505.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000023505.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7IB36; -.
DR Ensembl; ENSCJAT00000024865.4; ENSCJAP00000023505.2; ENSCJAG00000012810.5.
DR GeneTree; ENSGT00950000182860; -.
DR HOGENOM; CLU_033518_0_0_1; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000012810; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12069; SH3_ARHGAP27; 1.
DR CDD; cd00201; WW; 3.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF104; RHO GTPASE-ACTIVATING PROTEIN 27; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 3.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 255..283
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 302..336
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 420..447
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 477..593
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 679..868
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 69..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..89
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 96594 MW; F04617F4A37B64F2 CRC64;
MAADVEGDVY VLVEHPFEYT GKDGRRVAIR PNERYRLLRR STEHWWHVRS EPGGRPFYLP
AQYVRELPAL GNPAATPPPG PHPGPAAPKA PAPLAYDYRF LSAPGATGLD GAPAEPRGRA
SSLCGPAQRG TATQSSSLAP GLPACLYLRP AAPVRPAQSL DDLARTAVSP PAGLLGSSGS
FKACSVAGSW VCPRPLARSD SENIYEAIQD VRGPPRKESA EQADDPPEPV YANIERQPRA
TSPGASAAPL PSPVWETHTD AVTGRPYYYN PDTGVTTWES PFEAAEGAST PATSPASVGS
HVSFETEWGQ YWDEESRRVF FYNPLTGETA WEDEAEDEPE EELEMQPGLS PGSPRSPRPP
TPETDYPESL TSYPEEDYSP VGSFNEPRPT SPLSTPPGWS CHVSQDKQTV YTNHFTQEQW
VRLEDPHGKP YFYNPEDSSV RWELPQVPVP APRSIHKSSQ DSDTPAQASP PEEKTKTLDK
AGVLHRTKTA DKGKRLRKKH WSASWTVLEG GVLTFFKDSK TSAAGGLRQP SKFSTPEYTV
ELRGASLSWA PKDKSSKKNV LELRSRDGSE YLIQHDSEAI ISTWHKAIAQ GIHELSAELP
PEEETESSSV DFGSSERLGS LQEKEEDARP SAATPALGPG GLESDLSKVR HKLRKFLQRR
PTLQSLREKG YIKDQVFGCA LAALCERERS RVPRFVQQCI RAVEARGLDI DGLYRISGNL
ATIQKLRYKV DHDERLDLDD GRWEDVHVIT GALKLFFREL PEPLFPFSHF RQFIAAIKLQ
DQAQRSRCVR DLVRSLPAPN HDTLRLLFQH LCRVIEHGEQ NRMSVQSVAI VFGPTLLRPE
VEENSMPMTM VFQNQVVELI LQQCSDIFAP H
//
