ID F7ICE0_CALJA Unreviewed; 532 AA.
AC F7ICE0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Complement component C8 beta chain {ECO:0000256|ARBA:ARBA00013949};
DE AltName: Full=Complement component 8 subunit beta {ECO:0000256|ARBA:ARBA00031383};
GN Name=C8B {ECO:0000313|Ensembl:ENSCJAP00000029337.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000029337.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000029337.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000029337.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; F7ICE0; -.
DR Ensembl; ENSCJAT00000031002.5; ENSCJAP00000029337.5; ENSCJAG00000015932.5.
DR GeneTree; ENSGT00940000160247; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000015932; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF5; COMPLEMENT COMPONENT C8 BETA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 3: Inferred from homology;
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 100..446
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 510..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 82..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 532 AA; 59937 MW; 063FFFF241C133C6 CRC64;
MGLEVAGGDI SSLCCPGLSQ FAWLQYRHAY LLRPSQFHGE PCNFSDKEAE DCVANRPCRS
QVRCEGFVCA QTGRCVNRRL LCNGDNDCGD QSDEANCRRI YTKCQHEMDQ YWAIGALASG
INLFTNTLEG PVLDHRYYAG GCSPHYILNT RFRKPYNVES YTPQTQGKYE FALEEYESYS
DFEHNVMEKT IKKSSFGFGL KIPGIFELGI SSQSDQGKHY IKRIKRFSHT KSVFLHARSD
LEVAHYKLKS RSLMLHYEFL QRVKQLPLEY GYGEYRDLFR DFGTHYITEA VLGGIYEYTL
IMNKEAMERG DYTLNNVHAC AKNDFKIGGA IEGVYIKLGV SVGKCRGILN EIKDRKKRNT
MVEDLVVLVR GGASEHITTL AYKELPTADL MQEWGDAVQY NPAIIKVKVE PLYELVTATD
FAYSSTVRQN MKQALEEFQK EISSCQCAPC QGNGVPVLKE SHCDCICPAG FQGLACEISH
QKNISIDGKW NCWSNWSSCS GGHKTRQRQC NNPPPQNGGS PCSGPASETL NC
//
