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Database: UniProt
Entry: F7IDA9_CALJA
LinkDB: F7IDA9_CALJA
Original site: F7IDA9_CALJA 
ID   F7IDA9_CALJA            Unreviewed;      1843 AA.
AC   F7IDA9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   20-JUN-2018, entry version 52.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSCJAP00000011518};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011518, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000011518, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000011518}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   RefSeq; XP_002749429.1; XM_002749383.3.
DR   RefSeq; XP_002749430.1; XM_002749384.3.
DR   Ensembl; ENSCJAT00000012151; ENSCJAP00000011518; ENSCJAG00000006141.
DR   GeneID; 100389294; -.
DR   KEGG; cjc:100389294; -.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   KO; K04834; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    401    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    751    775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    787    808       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    870    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    960    983       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1209   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1587   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1753   1776       Helical. {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1843 AA;  209453 MW;  C6C3CBDEB116114E CRC64;
     MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK
     SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK
     LAIKILVHSY PFSNHNPPDW TKNVEYTFTG IYTFESLIKI LARGFCLEDF TFLRDPWNWL
     DFTVITFAYV TEFVDLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS VKKLSDVMIL
     TVFCLSVFAL IGLQLFMGNL RNKCLQWPPD NSSFEINITS FFNNSLDGNG TTFNRTVSMF
     NWDEYIEDKS HFYFLEGQND ALLCGNSSDA GQCPEGYICV KAGRNPNYGY TSFDTFSWAF
     LSLFRLMTQD FWENLYQLTL RAAGKTYMIF FVLVIFLGSF YLINLILAVV AMAYEEQNQA
     TLEEAEQKEA EFQQMLEQLK KQQEEAQAAA AAASAESRDF SGAGGIGVFS ESSSVASKLS
     SKSEKELKNR RKKKKQKEQS GEEEKSDRVR KSESEDSIRK KGFRFSLEGS RLTYEKRFSS
     PHQSLLSIRG SLFSPRRNSR ASLFSFRGRT KDIGSENDFA DDEHSTFEDN DSRRDSLFVP
     HRHGERRHSN VSQASRASRV LPILPMNGKM HSAVDCNGVV SLVGGPSTLT SAGQLLPEGT
     TTETEIRKRR SSSYHVSMDL LEDPTSRQRA MSIASILTNT MEELEESRQK CPPCWYKFAN
     MCLIWDCCKP WLKVKHLVNL VVMDPFVDLA ITICIVLNTL FMAMEHYPMT EQFSSVLSVG
     NLVFTGIFTA EMFLKIIAMD PYYYFQEGWN IFDGFIVSLS LMELGLANVE GLSVLRSFRL
     LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KSYKECVCKI
     SNDCELPRWH MHDFFHSFLI VFRVLCGEWI ETMWDCMEVA GQTMCLTVFM MVMVIGNLVV
     LNLFLALLLS SFSSDNLAAT DDDNEMNNLQ IAVGRMQKGI DFVKRKIREF IQKAFVRKQK
     ALDEIKPLED LNNKKDSCIS NHTTIEIGKD LNYLKDGNGT TSGIGSSVEK YVVDESDYMS
     FINNPSLTVT VPIAVGESDF ENLNTEEFSS ESDMEESKEK LNATSSSEGS TVDIGAPAEG
     EQPEAEPEES LEPEACFTED CVRKFKCCQI SIEEGKGKLW WNLRKTCYKI VEHNWFETFI
     VFMILLSSGA LAFEDIYIEQ RKTIKTMLEY ADKVFTYIFI LEMLLKWVAY GFQVYFTNAW
     CWLDFLIVDV SLVSLTANAL GYSELGAIKS LRTLRALRPL RALSRFEGMR VVVNALLGAI
     PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY HCINYTTGEM FDVSVVNNYS ECKALIESNQ
     TARWKNVKVN FDNVGLGYLS LLQVATFKGW MDIMYAAVDS RNVELQPKYE DNLYMYLYFV
     IFIIFGSFFT LNLFIGVIID NFNQQKKKIS QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR
     PANKFQGMVF DFVTKQVFDI SIMILICLNM VTMMVETDDQ SQEMTNILYW INLVFIVLFT
     GECVLKLISL RYYYFTIGWN IFDFVVVILS IVGMFLAELI EKYFVSPTLF RVIRLARIGR
     ILRLIKGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KREVGIDDMF
     NFETFGNSMI CLFQITTSAG WDGLLAPILN SGPPDCDPEK DHPGSSVKGD CGNPSVGIFF
     FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF EMFYEVWEKF DPDATQFIEF
     AKLSDFADAL DPPLLIAKPN KVQLIAMDLP MVSEHTLIMI IHL
//
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