ID F7IDE4_CALJA Unreviewed; 1001 AA.
AC F7IDE4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSCJAP00000047476.2};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSCJAP00000047476.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000047476.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000047476.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000047476.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7IDE4; -.
DR Ensembl; ENSCJAT00000058601.3; ENSCJAP00000047476.2; ENSCJAG00000010941.5.
DR GeneTree; ENSGT00940000155846; -.
DR HOGENOM; CLU_500517_0_0_1; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000010941; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 187..278
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 325..415
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 428..531
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 531..644
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 702..896
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 1001 AA; 110609 MW; AB9673924AA14DF8 CRC64;
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVRIPA ALPVAAAPYP GLVETGVAGT
LGGGAALGSG FLGTGSVAGA LGGAGLTGGG TAAGVAGAAA GVAGAAAAAA AAAAGPSGDM
SLTKLLTSLP AETLGPGGVF PPLPPPPHLP PLGAGLGTVD EGDSLDGPEY EEEEVAIPLT
APPTNQWYHG KLDRTIAEER LRQAGKSGSY LIRESDRRPG SFVLSFLSQM NVVNHFRIIA
MCGDYYIGGR RFSSLSDLIG YYSHVSCLLK GEKLLYPVAP PEASFQNFLK GDMFIVHNEL
EDGWMWVTNL RTDEQGLIVE DLVEEVVSFI SKQEAYNLLM TVGQVCSFLV RPSDNTPGDY
SLYFRTSENI QRFKICPTPN NQFMMGGRYY NSIGDIIDHY RKEQIVEGYY LKEPVPMQVR
FHNLLFAKSV LFVFLKKTGK GKRWKNLYFI LEGSDAQLIY FESEKRATKP KGLIDLSVCS
VYVVHDSLFD RPNCFQIVVQ HFSEEHYIFY FAGETPEQAE DWMKALQAFC SLRKSSPGTS
NKRLRQVSSL VLHIEEAHKL PVKHFTNPYC NIYLNSVQVA KTHAREGQNP VWSEEFVFDD
LPPDINRFEI TLSNKTKKSK DPDILFMRCQ LSRLQKGHAT DEWFLLSSHI PLKGIEPGSL
RVRARYSMEK IMPEEEYSEF KELILQKELH VVYALSHVCG QDRTLLASIL LRIFLHEKLE
SLLLCTLNDR EISMEDEATT LFRATTLAST LMEQYMKATA TQFVHHALKD SILKIMESKQ
SCELSPSKLE KNEDVNTNLA HLLNILSELV EKIFMASEIL PPTLRYIYGC LQKSVQDKWP
TNTTMRTRVV SGFVFLRLIC PAILNPRMFN IISDSPSPIA ARTLTLVAKS VQNLANLVEF
GAKEPYMEGV NPFIKSNKHR MIMFLDELGN VPELPDTTEH PRTDLSRDLA ALHEICVAHS
DELRTLSNER GAQQHVLKKL LAITELLQQK QHQYTKTNDV R
//
