ID   F7IJ25_CALJA            Unreviewed;       442 AA.
AC   F7IJ25;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=TTYH1 {ECO:0000313|Ensembl:ENSCJAP00000002125.4};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000002125.4, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000002125.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000002125.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. May be involved in cell adhesion.
CC       {ECO:0000256|ARBA:ARBA00037608}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   AlphaFoldDB; F7IJ25; -.
DR   Ensembl; ENSCJAT00000002243.5; ENSCJAP00000002125.4; ENSCJAG00000001214.6.
DR   eggNOG; KOG4433; Eukaryota.
DR   GeneTree; ENSGT00950000183060; -.
DR   HOGENOM; CLU_023758_1_0_1; -.
DR   TreeFam; TF319025; -.
DR   Proteomes; UP000008225; Chromosome 22.
DR   Bgee; ENSCJAG00000001214; Expressed in frontal cortex and 4 other cell types or tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF5; PROTEIN TWEETY HOMOLOG 1; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        43..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        88..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        214..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        242..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        392..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
SQ   SEQUENCE   442 AA;  47948 MW;  4A59AD3A2192FC66 CRC64;
     MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SGFAPQEQEY QQALLLVAAL AGLGLGLSLI
     FIAVYLIRFC CCRPPEPPGS KSPTPGGGCV TWSCIVALLV GCTGIGIGFY GNSETSDGVS
     QLSSALLHAN HTLSTIDHLV LETVERLGEA VRTELTTLEE VLEPRTELVA AARGAQLQAE
     VVAQQLQGLA FWQGVPLSPL QVAEDVSFME EYRWLAYVLL LLLELLVCLF TLLGLAKQSK
     WLVIVMTVMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDP YILNLTQEET GLSSDILSYY
     FLCNQAVSNP FQQRLSLSQR ALASIHSQLL GMERGAVRQF PSAQKPLLSL EETLNVTEGN
     FHQLVALLHC RGLHKDYGAA LRGLCEDALE GLLFLLLFSL LSAGALATAL CSLPQAWALF
     PPSTKLIPTP FPPRFVQWQS SI
//