ID   F7IJ93_CALJA            Unreviewed;       107 AA.
AC   F7IJ93;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Somatoliberin {ECO:0000256|ARBA:ARBA00040782};
DE   AltName: Full=Growth hormone-releasing factor {ECO:0000256|ARBA:ARBA00042164};
DE   AltName: Full=Growth hormone-releasing hormone {ECO:0000256|ARBA:ARBA00041953};
GN   Name=GHRH {ECO:0000313|Ensembl:ENSCJAP00000040060.3};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000040060.3, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000040060.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000040060.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: GRF is released by the hypothalamus and acts on the
CC       adenohypophyse to stimulate the secretion of growth hormone.
CC       {ECO:0000256|ARBA:ARBA00037623}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the glucagon family.
CC       {ECO:0000256|ARBA:ARBA00008369}.
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DR   AlphaFoldDB; F7IJ93; -.
DR   STRING; 9483.ENSCJAP00000040060; -.
DR   Ensembl; ENSCJAT00000042318.4; ENSCJAP00000040060.3; ENSCJAG00000021515.4.
DR   eggNOG; ENOG502S2N6; Eukaryota.
DR   GeneTree; ENSGT00950000183154; -.
DR   InParanoid; F7IJ93; -.
DR   OrthoDB; 4097249at2759; -.
DR   TreeFam; TF353187; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   Bgee; ENSCJAG00000021515; Expressed in ovary.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR   GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   InterPro; IPR046963; VIP/GHRH-like.
DR   PANTHER; PTHR11213; GLUCAGON-FAMILY NEUROPEPTIDE; 1.
DR   PANTHER; PTHR11213:SF6; SOMATOLIBERIN; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..107
FT                   /note="Somatoliberin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015362658"
FT   DOMAIN          32..54
FT                   /note="Glucagon / GIP / secretin / VIP family"
FT                   /evidence="ECO:0000259|PROSITE:PS00260"
SQ   SEQUENCE   107 AA;  12498 MW;  E5EA5365B4A38B40 CRC64;
     MPLWVFVFVI LTLSSSSHCF PHPPLALRMR RYTDAIFTNS YRKVLGQMSA RKLLQDIMSR
     QQGERNQERG ARARLGRQVD SVWAEQKQMA LESILVALRQ KHSRNQE
//