ID F7IQ02_CALJA Unreviewed; 682 AA.
AC F7IQ02;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSCJAP00000022474.5};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSCJAP00000022474.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000022474.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000022474.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000022474.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7IQ02; -.
DR Ensembl; ENSCJAT00000023771.5; ENSCJAP00000022474.5; ENSCJAG00000012239.6.
DR eggNOG; KOG3686; Eukaryota.
DR GeneTree; ENSGT00940000160935; -.
DR HOGENOM; CLU_010739_2_2_1; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000012239; Expressed in frontal cortex and 5 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 200..416
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 463..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 682 AA; 75012 MW; B50A1AB48F6AEA93 CRC64;
MDFLKYLLSS EFFEMLEKMQ GIKLEDQKPG PQKNKDDYIP YPSIDEVVEK GGPYPQVILP
QFGGYWIEDP ENVGTPTSLG SSICEEEEDN LSPNTFGYKL ECKGEARAYR RHFLGKDHLN
FYCTGSSLGN LILSVKCEEA EGIEYLRIIL RSKLKTVHER IPLVGLSKLP SVPQIAKAFC
DDAVGLKFNP VLYPKASQMI VSYDEHDVNN TFKFGVIYQK ARQTLEEELF GNNEESPAFK
EFLDLLGDTI MLQDFKGFRG GLDVTHGQTG VESVYTTFRD REIMFHVSTK LPFTEGDAQQ
LQRKRHIGND IVAIIFQEEN TPFVPDMIAS NFLHAYIVVQ VEAPGTETPS YKVSVTARED
VPTFGPPLPS PPVFQKGAEF REFLLTKLTN AENACCKSDK FAKLEDRTRA ALLDNLHDEL
HAHTQTMLGL GPEEDKFENG GHGGFLESFK RAIRVRSHSM ETMVGGQKKS HGGGIPGSLS
GGISHNSMEV TKTTFSQPPV VAATAKNQSR SPIKRRSGLF PRLHTGSEGQ GDSRARCDSV
SSTPKTPDGG HSSQEIKSET SSNPSSPEIC PNKEKPFMKL KENGRDISRS SSSTSSVSST
AGEGEAMEEG DSGSSQPSTS PFKQEVFVYS PSTSSESPSL GAAATPIIMS RSPTDAKSRN
SPRSNLKFRF DKLSHASSGA GH
//
