ID F7IT23_CALJA Unreviewed; 427 AA.
AC F7IT23;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Kininogen 1 {ECO:0000313|Ensembl:ENSCJAP00000026693.3};
GN Name=KNG1 {ECO:0000313|Ensembl:ENSCJAP00000026693.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000026693.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000026693.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000026693.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
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DR RefSeq; XP_008979605.1; XM_008981357.1.
DR AlphaFoldDB; F7IT23; -.
DR Ensembl; ENSCJAT00000028213.4; ENSCJAP00000026693.3; ENSCJAG00000014495.5.
DR GeneTree; ENSGT00950000182930; -.
DR OrthoDB; 5223498at2759; -.
DR Proteomes; UP000008225; Chromosome 15.
DR Bgee; ENSCJAG00000014495; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 3.
DR Gene3D; 3.10.450.10; -; 3.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF12; KININOGEN-1; 1.
DR Pfam; PF00031; Cystatin; 3.
DR SMART; SM00043; CY; 3.
DR SUPFAM; SSF54403; Cystatin/monellin; 3.
DR PROSITE; PS00287; CYSTATIN; 2.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasodilator {ECO:0000256|ARBA:ARBA00022429}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..427
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015348951"
FT DOMAIN 28..132
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 151..254
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT DOMAIN 273..376
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
FT REGION 401..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 48056 MW; 0F178B68F2CE251B CRC64;
MKLITILFLC SRLLLGLTQE SQSEEIDCND KDLFEAVDAA LKKYNNENLT TNQFVLYRIT
EGTKMVGSDT FYSFKYEIKE GDCPHQNGKT WQDCDYKDAA EAATGECTAT VGKRGNTKFS
VAMQSCQITP ANGPVMTARY SCLGCVHPVS TKSPDLDPIL RHGVQYFNNN TNHSSLFMLS
EVKRAQRQVV SGWNFLITYS IVQTNCSKEN FLFLTPDCKS LWNGDIGECT DDAYMDIQLR
ITSFSQKCDI YPGEDFVQPP IKLCVGCPRD IPTNSPELEE TLTHTITKLN AENNETFYFK
IDNVKRARVQ VVAGKKYFID FVARETTCSK ESNEELTKSC EARNPGQSLD CSAEVYVVPW
EKKIYPTVKC EPLGMISLMK RPPGFSPFRT LQAGEIREET TSHLRSCEYK GRPPKAGAEP
ASEREVS
//
