ID F7JIR2_9FIRM Unreviewed; 872 AA.
AC F7JIR2;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=FtsK domain-containing protein {ECO:0000259|PROSITE:PS50901};
GN ORFNames=HMPREF0988_00216 {ECO:0000313|EMBL:EGN32431.1};
OS Lachnospiraceae bacterium 1_4_56FAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658655 {ECO:0000313|EMBL:EGN32431.1, ECO:0000313|Proteomes:UP000004289};
RN [1] {ECO:0000313|EMBL:EGN32431.1, ECO:0000313|Proteomes:UP000004289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1_4_56FAA {ECO:0000313|EMBL:EGN32431.1,
RC ECO:0000313|Proteomes:UP000004289};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 1_4_56FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN32431.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACTN01000004; EGN32431.1; -; Genomic_DNA.
DR AlphaFoldDB; F7JIR2; -.
DR STRING; 658655.HMPREF0988_00216; -.
DR PATRIC; fig|658655.3.peg.212; -.
DR eggNOG; COG1674; Bacteria.
DR HOGENOM; CLU_001981_9_2_9; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000004289; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000004289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 515..711
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 225..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 533..540
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 872 AA; 95338 MW; 2C51D1E3064DB4D5 CRC64;
MAAKSTKKRK NSRGKKKKTQ EYSVLHGEII ILCVLAVCIF LMISCFGLGG IAGEICSSVI
FGLFGWVGYV IPILIFGVVA FLISNKGNTH AYIKTAAAIV LVCLVAAFLE LVVNSYTPGT
GLMEHYRQAS IRKDAGGLLG GAQVQLLCPM LGVVGAYIAI VILAVISVIL ITERSLLKPL
SHGGKRVYED AKIRHETAAI RAAKKREERR QTRVLRLEAL QAEAEKERVQ KQNEEKKESK
KARRQDQKVS GVSFATTLSD GPSKRKSPEV QELIPDLPMD EKPQDIPFPS PFDETQGDDL
PETAFVINRA DDRIEAEQAE ETNIWGEEPR ALDSEVNDGE QVSASPAKKK TTKQDIQEIA
AETQNVEAEI KEKEEQPKPV YKIPPLRLLK RGKKGGGDSD AHLRATALKL EQTLQNFGVK
VHVTNASCGP SVTRYEIQPE QGVKVSKIVG LADDIKLNLA VTDLRIEAPI PGKAAVGIEV
PNSENSAVML RDLLEAEDFQ KSKSNLTVAV GKDIAGKVVI ADIAKMPHLL VAGSTGSGKS
VCINTLIMSM IFKSDPEDVK LIMVDPKVVE LSVYNGIPHL LIPVVTDPKK AAGALNWAVA
EMMKRYQMFA EYNVRDLKGF NEKILQMEPG EGVPKKMAQI VIIVDELADL MMVAPKDVEG
AICRLAQLAR AAGIHLILAT QRPSVNVITG LIKANMPSRI AFAVSSGVDS RTIIDMNGAE
KLLGKGDMLF YPTGYPKPVR VQGSFVSDKE VQQVVEYLIE NNGNASYSNE LEEHMNAELE
TENGSISIAA PGMENSSDAR DQYFADAGYL IIEKEKASIG MLQRMFKIGF NRAARIMDQL
ADVGVVGPEE GTKPRKVLMT KEEFEQYLSE NK
//
