ID F7K407_9FIRM Unreviewed; 809 AA.
AC F7K407;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN ORFNames=HMPREF0994_00591 {ECO:0000313|EMBL:EGN44779.1};
OS Lachnospiraceae bacterium 3_1_57FAA_CT1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658086 {ECO:0000313|EMBL:EGN44779.1, ECO:0000313|Proteomes:UP000003336};
RN [1] {ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGN44779.1, ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|EMBL:EGN44779.1,
RC ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M.,
RA Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN44779.1}.
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DR EMBL; ACTP02000001; EGN44779.1; -; Genomic_DNA.
DR AlphaFoldDB; F7K407; -.
DR STRING; 658086.HMPREF0994_00591; -.
DR PATRIC; fig|658086.3.peg.643; -.
DR eggNOG; COG1345; Bacteria.
DR HOGENOM; CLU_015182_0_0_9; -.
DR Proteomes; UP000003336; Unassembled WGS sequence.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR010810; Flagellin_hook_IN_motif.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07196; Flagellin_IN; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362066};
KW Reference proteome {ECO:0000313|Proteomes:UP000003336};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 27..130
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 515..797
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
FT COILED 753..780
FT /evidence="ECO:0000256|RuleBase:RU362066"
SQ SEQUENCE 809 AA; 86015 MW; D949FEBC3137E120 CRC64;
MASIGGLSSN ASTNSASSLR GYGGLASGLD RDSLIESMTY ATTSKIQKQQ QAKQKITWTQ
EAMRGITDKL YNFSQSFISY TSPKSLLSTK LFSSNQITAL GENSKYIGVS GSSSLAKSMS
IAGVKQMASD AKCNFTGAAS DQKLASGGID EDLSTLNDYS TVAGTSFTVK YGSKYYSVSL
PENSEDYKYD TLSDVAASIN KAMGEISVGD GKTLADAMAV SEDGSRLTFT NKDTAGNALE
LTGSSDNLLG NLGFQFGQDN KGIEITSSGV RGSSNAKLTE QKSVADQIGG KQICFTYNGK
TEWIQLASAA DLKDPTKGNN DLDYLVSDLQ AKLDKAFGAG RINVKADSTA TPGQSSLSFK
TTVPTNNNSI VEDKSSVLSL AAGERGLLGQ YGALTGLSAG DSNRLNLESS WTKSGLKHME
GMTDAQIAAL PDEDTLKING TEIKIKKGMS LTDIMDAINA SDAGVKASYL AEGDRFVLTS
TENGASGKIE IDSDQGIDQL LFGVKGTDYE VQEGKDAIIA VKYAGSDTPV EVTRGSNSFN
LNGLTVTVKG EFGYNSGVLD PAAEAITFDV TMNTEPAVTA VKEMVDAFNE IVKLVNDEVS
TKPNRKYDPL TAEQEDEMSE SQINAWNEKA KAGMLFNDSD IRGLADALRT IISGDASNMQ
KMGLSVSTDY SDNGKLVFDE EAFKKALETD PDGVINAFTR PAEKDANGNV TDAGGVMVRL
QTIMEKYAST TGATKGILIE RAGSKYAPTS ILTNSMQKQL DAIDKEIDRL TDKLSVEQDR
YISQFTNLER LISQMNSQSS WLASAFGGA
//
