ID F7KCR6_9FIRM Unreviewed; 995 AA.
AC F7KCR6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Beta-xylanase {ECO:0000256|RuleBase:RU361174};
DE EC=3.2.1.8 {ECO:0000256|RuleBase:RU361174};
GN ORFNames=HMPREF0994_03645 {ECO:0000313|EMBL:EGN39017.1};
OS Lachnospiraceae bacterium 3_1_57FAA_CT1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658086 {ECO:0000313|EMBL:EGN39017.1, ECO:0000313|Proteomes:UP000003336};
RN [1] {ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 2_1_58FAA.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGN39017.1, ECO:0000313|Proteomes:UP000003336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3_1_57FAA_CT1 {ECO:0000313|EMBL:EGN39017.1,
RC ECO:0000313|Proteomes:UP000003336};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Allen-Vercoe E., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M.,
RA Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 3-1-57FAA CT1.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.;
CC EC=3.2.1.8; Evidence={ECO:0000256|RuleBase:RU361174};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 10 (cellulase F) family.
CC {ECO:0000256|RuleBase:RU361174}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGN39017.1}.
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DR EMBL; ACTP02000012; EGN39017.1; -; Genomic_DNA.
DR AlphaFoldDB; F7KCR6; -.
DR STRING; 658086.HMPREF0994_03645; -.
DR PATRIC; fig|658086.3.peg.3977; -.
DR eggNOG; COG1653; Bacteria.
DR eggNOG; COG3693; Bacteria.
DR HOGENOM; CLU_291479_0_0_9; -.
DR Proteomes; UP000003336; Unassembled WGS sequence.
DR GO; GO:0031176; F:endo-1,4-beta-xylanase activity; IEA:UniProtKB-EC.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 2.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR044846; GH10.
DR InterPro; IPR031158; GH10_AS.
DR InterPro; IPR001000; GH10_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR31490:SF88; BETA-XYLANASE; 1.
DR PANTHER; PTHR31490; GLYCOSYL HYDROLASE; 1.
DR Pfam; PF13229; Beta_helix; 1.
DR Pfam; PF00331; Glyco_hydro_10; 1.
DR PRINTS; PR00134; GLHYDRLASE10.
DR SMART; SM00633; Glyco_10; 1.
DR SMART; SM00710; PbH1; 3.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS00591; GH10_1; 1.
DR PROSITE; PS51760; GH10_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU361174};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361174};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361174};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326,
KW ECO:0000256|RuleBase:RU361174};
KW Reference proteome {ECO:0000313|Proteomes:UP000003336}.
FT DOMAIN 1..339
FT /note="GH10"
FT /evidence="ECO:0000259|PROSITE:PS51760"
FT ACT_SITE 257
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10061"
SQ SEQUENCE 995 AA; 113014 MW; 11E3DF004EAA988E CRC64;
MSLKTVYQPY FKMGAAVPAQ VFESTTALGE LCVQYDSMTC ENEMKPQFLL DEEENRRNAA
QYDRCPAVCF EGVRKYLDFA REHGMKMRGH TLVWHNQTPR WFFAEGYRGE EDAPLADRET
MLARLEGYIR QVLEFTQTEY PGIIYAWDVV NEAVEDGTLR RSLWTETVGE DFILQAFRFA
RKYAKQDVSL FYNDYDTFIP WKRDVICEQV LKPLLSEQLV DGMGMQSHMT MNTPDLEEYE
KSLRVYGSLG IQIQVTELDI HNADPSASSM EALAARYREV FTILIRNKKE GAADVTGVTF
WGMQDDDSWL TGFRGERSFP LLFQDGFRPK TAYQAVLSVP GRVEGDTQDR LPGGERFAFW
EKTPVFTREY HVNAAHPEAC DENDGSMEHP FATIQAAANL AGPGTRVWIH GGVYRECVHP
VCGGNGPEEM VSFEAFGDGE AVIKASVETH DFRRSEGWNL IPPGVQVSLP EGLQIWETRL
NPDEFRGYNP FCAVNILHDR LFIEYEKTDM TTYLNRRGMV FCDGKPLKQV SLYNQLGSTP
GSYWVEANGQ TVHFRLEDDS DPAQHQIELT CREQCFAPEI PFLSYIRVKG LTCAHAATGA
PVPQRGAISC YRGHHWIIED CKIDWSNGVG IDIGNECWHH TFRENQIIGH TVVRGCEIRD
AGVCGIAGMF ATDLLIEDNR IEGTGWQKME LSWEAGGIKV HNSVNSLIRR NIFTKTFRAD
HLWMDVGNEN NRITRNLFLD GIEQREAIFI ECSRDGINLI DNNIFWNVEG RFRPEDIPSE
PGSTGWYKME ETGEINGYAV YGEGTDRLHV VNNFIGRCRS AGYFVKPVAF RISGNGRGGT
SREARIVNNM FYDCGEAAIK FPTKDNDSQG NLYVKMPGGY LRILYPAPEN CLDLQAWQEF
YGFDKEGQEG FFTVEVDTEK LTLELKKADG LPEMRHHGTG RQNYITEPEK VLPVKASMET
ADAFDGDACG ERRVPGPFAV LETGRIYELD PRKRK
//
