ID F7QHA6_9BRAD Unreviewed; 544 AA.
AC F7QHA6;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=peptidoglycan lytic exotransglycosylase {ECO:0000256|ARBA:ARBA00012587};
DE EC=4.2.2.n1 {ECO:0000256|ARBA:ARBA00012587};
DE AltName: Full=Murein hydrolase A {ECO:0000256|ARBA:ARBA00030918};
GN ORFNames=CSIRO_0933 {ECO:0000313|EMBL:EGP09395.1};
OS Bradyrhizobiaceae bacterium SG-6C.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae.
OX NCBI_TaxID=709797 {ECO:0000313|EMBL:EGP09395.1, ECO:0000313|Proteomes:UP000003148};
RN [1] {ECO:0000313|EMBL:EGP09395.1, ECO:0000313|Proteomes:UP000003148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG-6C {ECO:0000313|EMBL:EGP09395.1,
RC ECO:0000313|Proteomes:UP000003148};
RX PubMed=21742875; DOI=10.1128/JB.05647-11;
RA Pearce S.L., Pandey R., Dorrian S.J., Russell R.J., Oakeshott J.G.,
RA Pandey G.;
RT "Genome Sequence of the Newly Isolated Chemolithoautotrophic
RT Bradyrhizobiaceae Strain SG-6C.";
RL J. Bacteriol. 193:5057-5057(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exolytic cleavage of the (1->4)-beta-glycosidic linkage
CC between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine
CC (GlcNAc) residues in peptidoglycan, from either the reducing or the
CC non-reducing ends of the peptidoglycan chains, with concomitant
CC formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n1;
CC Evidence={ECO:0000256|ARBA:ARBA00001420};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGP09395.1}.
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DR EMBL; AFOF01000013; EGP09395.1; -; Genomic_DNA.
DR AlphaFoldDB; F7QHA6; -.
DR STRING; 709797.CSIRO_0933; -.
DR eggNOG; COG2821; Bacteria.
DR HOGENOM; CLU_037751_0_0_5; -.
DR Proteomes; UP000003148; Chromosome.
DR GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009254; P:peptidoglycan turnover; IEA:InterPro.
DR CDD; cd14668; mlta_B; 1.
DR CDD; cd14485; mltA_like_LT_A; 1.
DR Gene3D; 2.40.240.50; Barwin-like endoglucanases; 1.
DR Gene3D; 2.40.40.10; RlpA-like domain; 1.
DR InterPro; IPR010611; 3D_dom.
DR InterPro; IPR026044; MltA.
DR InterPro; IPR005300; MltA_B.
DR InterPro; IPR036908; RlpA-like_sf.
DR PANTHER; PTHR30124; MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A; 1.
DR PANTHER; PTHR30124:SF0; MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE A; 1.
DR Pfam; PF06725; 3D; 1.
DR Pfam; PF03562; MltA; 1.
DR SMART; SM00925; MltA; 1.
DR SUPFAM; SSF50685; Barwin-like endoglucanases; 1.
PE 4: Predicted;
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW Glycosidase {ECO:0000313|EMBL:EGP09395.1};
KW Hydrolase {ECO:0000313|EMBL:EGP09395.1};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 135..293
FT /note="Lytic transglycosylase MltA"
FT /evidence="ECO:0000259|SMART:SM00925"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 59449 MW; A99CDE80CCD19DEF CRC64;
MTVNAQARPA GRHHTSHGPH HELGKRAPVD WPLEIPGGQY EPLTWNEVAG WTDDDQLPAF
KTFRASCKPI VAQKGALNDS KALGTSLRDP CLAARAENIA DSAKAREFFE KNFTPLQISR
IGEDAGFVTG YYEPIVDGSR TQTDVYNVPV YRRPSNLFVR GYSQASASMP NKGQVFRKIG
RRKLVPYYDR AEIEDGAIAG RGLEVVWLKS QTDLLFIQIQ GSARIRLEDG SMVRINYDAH
NGYPYTPVGR VLIERNIVPK EQMSMQKIRE YMEQNPDAAK ELRRFNRSYV FFREVKLAAD
DEAVGAQGVP LTAGRSIAVD KSLHVYGTPF FIEGKLPIES ETSNTPFRKL MIAQDTGSAI
IGPARADIYF GAGAEAGRIA GRLKNPARFV MLLPNSLNPS PRGKTVPLPD ERPSATIAKL
FPQTGPAKEA AADAPKETAK DQPKADPSKT DSSKSEQKTA PKDQPADANK TVAPKEAPAV
QAPQVAPSAA TPSTPAAAVV PPVAQAVPLP DARPKTAPEA AAPSAVKSDT TRRSRHHRRH
RHRR
//
