ID F7UYD8_EEGSY Unreviewed; 456 AA.
AC F7UYD8;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Glucosylceramidase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=EGYY_03550 {ECO:0000313|EMBL:BAK43588.1};
OS Eggerthella sp. (strain YY7918).
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=502558 {ECO:0000313|EMBL:BAK43588.1, ECO:0000313|Proteomes:UP000008929};
RN [1] {ECO:0000313|EMBL:BAK43588.1, ECO:0000313|Proteomes:UP000008929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YY7918 {ECO:0000313|EMBL:BAK43588.1,
RC ECO:0000313|Proteomes:UP000008929};
RX PubMed=21914883;
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp.
RT Strain YY7918, Isolated from Adult Human Intestine.";
RL J. Bacteriol. 193:5570-5571(2011).
RN [2] {ECO:0000313|Proteomes:UP000008929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YY7918 {ECO:0000313|Proteomes:UP000008929};
RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT "Complete genome sequence of the equol-producing bacterium Eggerthella sp.
RT strain YY7918 isolated from adult human intestine.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
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DR EMBL; AP012211; BAK43588.1; -; Genomic_DNA.
DR RefSeq; WP_013978838.1; NC_015738.1.
DR AlphaFoldDB; F7UYD8; -.
DR KEGG; eyy:EGYY_03550; -.
DR eggNOG; COG5520; Bacteria.
DR HOGENOM; CLU_014379_1_1_11; -.
DR OrthoDB; 9806701at2; -.
DR Proteomes; UP000008929; Chromosome.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR PRINTS; PR00843; GLHYDRLASE30.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Reference proteome {ECO:0000313|Proteomes:UP000008929};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 41..383
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 386..446
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
SQ SEQUENCE 456 AA; 51450 MW; 7CA73AA89BA41954 CRC64;
MRCYTTDGRG AFRHTDRAFH RDERAEMGLV VCRPDKTYQR IVGFGGAFTE AAASVFAQMP
PDVQDDFLLQ CFGRAPEVHA GQGGNAYTLC RTHIQSCDFA LGNYAYVRPF DRALQTFSIS
RDQQLLLPFI KCGLAVNPHF QLFASPWSPP AFMKTNRRMN GGGRLRHSCY EAWANLLVRY
VDAYAREGVR IGRMSIQNEP MACQTWDSCL FTAEEEAEFA AHFLRPALDA AGYEDVVLFA
WDHNTDRILE RVEATFAYPD ADAAFGGCAL HWYAGDHFEQ VRAVAEAYPN KELLFTEGCV
EYSLDQAKEA TQERKAEQYA HAVIGHLNAG AHGFIDWNLL LDERGGPNHV GNFCEAPLMY
DRAAQQLIVN RSFHYLGHFS RFVVPGSQRF LTSRFTDDIE CVGFVRPDST RVLVILNRRA
HEARLSVAER PWVARVEVPA HSIVTLTWDS NEVCAP
//
