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Database: UniProt
Entry: F7V683_CLOSS
LinkDB: F7V683_CLOSS
Original site: F7V683_CLOSS 
ID   F7V683_CLOSS            Unreviewed;       580 AA.
AC   F7V683;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE            Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   OrderedLocusNames=CXIVA_22950 {ECO:0000313|EMBL:BAK48262.1};
OS   Clostridium sp. (strain SY8519).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1042156 {ECO:0000313|EMBL:BAK48262.1, ECO:0000313|Proteomes:UP000008937};
RN   [1] {ECO:0000313|Proteomes:UP000008937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SY8519 {ECO:0000313|Proteomes:UP000008937};
RX   PubMed=21914882; DOI=10.1128/JB.05637-11;
RA   Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT   "Complete genomic sequence of the O-desmethylangolensin-producing bacterium
RT   Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human
RT   intestine.";
RL   J. Bacteriol. 193:5568-5569(2011).
CC   -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC       Ala-charged tRNA and directs the elongation of stalled nascent chains
CC       on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC       extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC       May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC       ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC       Rule:MF_00844}.
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DR   EMBL; AP012212; BAK48262.1; -; Genomic_DNA.
DR   RefSeq; WP_013978219.1; NC_015737.1.
DR   AlphaFoldDB; F7V683; -.
DR   STRING; 1042156.CXIVA_22950; -.
DR   KEGG; cls:CXIVA_22950; -.
DR   eggNOG; COG1293; Bacteria.
DR   HOGENOM; CLU_022481_2_1_9; -.
DR   OMA; SWHPQAA; -.
DR   OrthoDB; 9766163at2; -.
DR   Proteomes; UP000008937; Chromosome.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.8.50; -; 1.
DR   Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR   HAMAP; MF_00844_B; RqcH_B; 1.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR   InterPro; IPR043682; RqcH_bacterial.
DR   PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   PANTHER; PTHR15239:SF6; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   Pfam; PF18297; NFACT-R_2; 1.
DR   Pfam; PF05833; NFACT_N; 1.
DR   SUPFAM; SSF46946; S13-like H2TH domain; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000008937};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00844};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW   Rule:MF_00844}.
FT   DOMAIN          461..553
FT                   /note="NFACT RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF05670"
FT   COILED          391..425
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ   SEQUENCE   580 AA;  66157 MW;  8F492A2D3D87A6E8 CRC64;
     MAYDGIAVSN IRHDLAEEFT GGRISKIAQP EKDELLLTLK GTDGQKRLLI SASPSLPVIY
     LTEENKKSPM TAPNFCMLLR KHVSGGRIVN ITQPGFERIL IFEIEHLDDL GDLCRKQLIV
     ELMGKHSNII FCDASGRILD SIKHISANIS SVREVLPGRQ YFIPRQEGKT SPLDLTDGQA
     LIQRLKSRPM PAARAIYSSY TGFSPLAAQE ICYRAGIDGD APVDSVTALQ WDRLAETWIH
     FMDAIRNGDF YPNMILDEGR PLEFASYHLT MYRDKETVPY DTVSHLLVDY YAKKAADTRI
     HQKSADLRHQ VNVLLERTRK KYYLQQKQKK DTEKRDKYRK YGEMIHAYSY LLKKGMAGFE
     NTDYETGKQM QVPLNKDLTP MENAAKYFAR YNKLKRTDEA LTIQLQETKD DLTHLESIAA
     SLEIAENEAD LVQIRQELAD AGYLKRPSGK QKKSREVSQP YHYRSSDGFD IYVGKNNIQN
     DALTFRFAQG NDWWFHAKGM PGSHVIVRCK TGELPDRTFE EAGRLAGYYS AGRGSEKVEI
     DYLQKKNVKK PNKAKPGFVV YYTNYSLTID TDITGIERIE
//
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