ID F7VJM5_RABIT Unreviewed; 55 AA.
AC F7VJM5;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Spermatid nuclear transition protein 1 {ECO:0000256|ARBA:ARBA00015111};
GN Name=Tnp1 {ECO:0000313|EMBL:DAA34871.1};
GN Synonyms=TNP1 {ECO:0000313|Ensembl:ENSOCUP00000022680.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|EMBL:DAA34871.1};
RN [1] {ECO:0000313|EMBL:DAA34871.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18562159; DOI=10.1016/j.ygeno.2008.05.001;
RA Kleene K.C., Bagarova J.;
RT "Comparative genomics reveals gene-specific and shared regulatory sequences
RT in the spermatid-expressed mammalian Odf1, Prm1, Prm2, Tnp1, and Tnp2
RT genes.";
RL Genomics 92:101-106(2008).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022680.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022680.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [3] {ECO:0000313|Ensembl:ENSOCUP00000022680.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022680.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the nuclear transition protein 1 family.
CC {ECO:0000256|ARBA:ARBA00005481}.
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DR EMBL; AAGW02042659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006507; DAA34871.1; -; Genomic_DNA.
DR RefSeq; XP_002712515.1; XM_002712469.3.
DR STRING; 9986.ENSOCUP00000022680; -.
DR PaxDb; 9986-ENSOCUP00000022680; -.
DR Ensembl; ENSOCUT00000026120.1; ENSOCUP00000022680.1; ENSOCUG00000021367.1.
DR GeneID; 100349146; -.
DR KEGG; ocu:100349146; -.
DR CTD; 7141; -.
DR eggNOG; ENOG502TKT1; Eukaryota.
DR GeneTree; ENSGT00390000000539; -.
DR HOGENOM; CLU_3019482_0_0_1; -.
DR OMA; FKSHGMR; -.
DR TreeFam; TF338391; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000021367; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0031507; P:heterochromatin formation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0006337; P:nucleosome disassembly; IEA:Ensembl.
DR GO; GO:0010954; P:positive regulation of protein processing; IEA:Ensembl.
DR GO; GO:0000012; P:single strand break repair; IEA:Ensembl.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:Ensembl.
DR GO; GO:0007290; P:spermatid nucleus elongation; IEA:Ensembl.
DR InterPro; IPR001319; Nuclear_transition_prot1.
DR InterPro; IPR020062; Nuclear_transition_prot1_CS.
DR PANTHER; PTHR17486; SPERMATID NUCLEAR TRANSITION PROTEIN 1; 1.
DR PANTHER; PTHR17486:SF0; SPERMATID NUCLEAR TRANSITION PROTEIN 1; 1.
DR Pfam; PF02079; TP1; 1.
DR PROSITE; PS00541; TP1; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 55 AA; 6424 MW; FA7408245EADE355 CRC64;
MSTSRKLKSH GMRRGKNRSP HKGVKRGGSK RKYRKGSLKS RKRSDDANRN YRSHL
//
