ID F7VSA1_SORMK Unreviewed; 739 AA.
AC F7VSA1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=SMAC_01933 {ECO:0000313|EMBL:CCC08387.1};
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC08387.1, ECO:0000313|Proteomes:UP000001881};
RN [1] {ECO:0000313|EMBL:CCC08387.1, ECO:0000313|Proteomes:UP000001881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC {ECO:0000313|Proteomes:UP000001881};
RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC08387.1};
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCC08387.1}.
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DR EMBL; CABT02000005; CCC08387.1; -; Genomic_DNA.
DR RefSeq; XP_003348911.1; XM_003348863.1.
DR AlphaFoldDB; F7VSA1; -.
DR GeneID; 10806370; -.
DR KEGG; smp:SMAC_01933; -.
DR VEuPathDB; FungiDB:SMAC_01933; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR HOGENOM; CLU_008878_3_1_1; -.
DR InParanoid; F7VSA1; -.
DR OMA; GCPTNAK; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF4; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000001881};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 271..509
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 591..724
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 672
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
SQ SEQUENCE 739 AA; 80170 MW; D422F6AD1566047C CRC64;
MASSVSGPTP PGLPPLPPGH GDYYTETQWT VLMSLLDATI PSITAVSNKK DDKTQLGLAD
AEFKEIVTNA QASVVKKPAV EDITAYLAER ASDDPAFCCA MRRTLSTVPA SARNQLGAVL
YALSTRPGSL LLTGYATPIQ DQPLHIRESI LRSWATSWFG TPRVLFKTFT VIAKVIWLQT
SPLFRTVTGF PDVPVNWNPG RTEGFGFLQF DTSVNEPATV ETDVVIIGSG CGGGVCAKVL
AEAGHRVLVV EKGYYFDPSQ LPMPRDQGGF HLFENNGFVN SVDSSINVVA GSCWGGGGSI
NWSVSLQTQG YVRKEWSEQH GLPFFESGEY QTCLDRVCEF MGVVGGDDVR QSYRGQKLLD
GSRKLGYAAQ VCPQNSGGKE HWCGHCHLGC ASAEKQGPAV SWLPAAAKRG ATFMEGFSAD
RILWDESESS LSWFGFGGNN NKRRAVGVEG TWTARDTKGG VTGEQKTRKV IIKAKKVIVA
AGTLNSPLIL QKSGLNSRHI GRNLYLHPVN FLGAYYEDDV KPWEGGIITS VCTAFENLDG
QGHGVKLEGT CMLPYAILTQ LPWRGALAYK LACLRYRHLN AWISLARDRD TGRVYADPIT
GKPSIEYTVS PFDAAHILEG LIALAKIAYV SEQPASEEDY DKGVKDPLFE SWLKTLRERG
NAPPYPPYTS AHQMGTCRMS STPENGVVDP KGKVWGTEGL YVADASVFPS ASGVNPMITN
MAIADWIARG VVGEFGKKI
//
