ID F7VWS1_SORMK Unreviewed; 1140 AA.
AC F7VWS1;
DT 21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT 21-SEP-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=SMAC_02542 {ECO:0000313|EMBL:CCC09962.1};
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC09962.1, ECO:0000313|Proteomes:UP000001881};
RN [1] {ECO:0000313|EMBL:CCC09962.1, ECO:0000313|Proteomes:UP000001881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC {ECO:0000313|Proteomes:UP000001881};
RC TISSUE=Mycelium {ECO:0000313|EMBL:CCC09962.1};
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCC09962.1}.
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DR EMBL; CABT02000011; CCC09962.1; -; Genomic_DNA.
DR RefSeq; XP_003352107.1; XM_003352059.1.
DR AlphaFoldDB; F7VWS1; -.
DR STRING; 771870.F7VWS1; -.
DR GeneID; 10809727; -.
DR KEGG; smp:SMAC_02542; -.
DR VEuPathDB; FungiDB:SMAC_02542; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_004183_0_0_1; -.
DR InParanoid; F7VWS1; -.
DR OMA; EFQFRPM; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001881};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..443
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 654..694
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 984..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 126877 MW; 2858190C937D1152 CRC64;
MLTFGRTTEA PVLPPDHPLR TAFSRYGTWT ARHVKTVLPM SVALVFLLLY PIFFLYTTDA
TNVTSGVSNL PHHVWTDAQP LSERAVVEPD VIMRSIWVHG SYMKALDREV LLGALELQNT
LLGPTTDFNP RRPNAPRILP DDPTVDMTRD QRDAFHIVNG LTDQSWFFHS PLQYWGGSAD
NIVADKDIIS TVNEKKTQST SVNVTLRHSI VFSGKRFEER RLVAADALVI TLIHLRDCPL
GQQWVRNAER LAAQVQDKYT VIPHDGKSMA SQLYEFQFRP MSWPDWFLLT IAYSLTLFYL
LLSLSKLRAV KSRFGLMATI LAQIAASIGS SFTVCAIFKI DLSRVPYYAY PLVVLAISME
NSFRLINAVI MTSSSISISD RIGEAFGQTA YVAVANRLQN LAILLGLSRI TFPGVAAFCT
FAAVAIIFDF LYLATFFLAV LSVDVRQREL YELEKASVRK TNAIYETSLL DRIRRIRHSG
VTVSTRVAGT IVILGFILLA QSHYALESGS QWVHWIFTSS WRVAEPVISK SSLLVDIHQA
RSPTSWLRLQ DHETAREVIN VVKPWAHSYV ARVYEPLIFV AKGADRIPHS PEPMFLPAVY
DFIHNEIPRF LVFMLTLVAL LLLLTNYLLQ GNGKHASDPD HPDNEPLLSV RSLSHGHDLD
VVKMAVSPGN KLVSVGLDRN IQIWDVPLNS RTRVMSDSET PLENPFPVLA MAIDDDSKWL
ALLTWQRIFL WDTDEQQWGL SLEVDLGGHK PEAVFFNYAN KPLDSPSLVI VRKNGTMLEL
DLEDGASKEF TICKTPFSMA LPFAELKLHP RSEAATWRVD SKEAKITTGE AKDIHSIVPA
PDLSMYLICR SRSVDLVDLE SSAVIQTFNT EPMEPRSLKL LLSSRGAPQH GLPPLSLCYI
SSETGDLVIQ TFHRADEADP VHHPKDHVPE APRQPWDEEK EVKKRIENPG RWEILPNGGI
VGVRRVPVAS SSSLRRRSFQ AMSSGVGVGS GLRRRGGAAA TTNNSTADST DSTTPDIGTA
TWQAWAFNNL ESARTKGIET QPLDQQVDDE EEQDTSMYDN LLVSELGPMV RLGTASVAVG
LGNVIKVISV GHEHFDKVVT RDRLTAENLR NQNFVRRRKT GVAAHRARGG VAAGAGAGGI
//
